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A novel secondary acyl chain in the lipopolysaccharide of Bordetella pertussis required for efficient infection of human macrophages.

Geurtsen J, Angevaare E, Janssen M, Hamstra HJ, ten Hove J, de Haan A, Kuipers B, Tommassen J, van der Ley P. Geurtsen J, et al. Among authors: hamstra hj. J Biol Chem. 2007 Dec 28;282(52):37875-84. doi: 10.1074/jbc.M706391200. Epub 2007 Oct 29. J Biol Chem. 2007. PMID: 17967899

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Expression of the lipopolysaccharide-modifying enzymes PagP and PagL modulates the endotoxic activity of Bordetella pertussis.

Geurtsen J, Steeghs L, Hamstra HJ, Ten Hove J, de Haan A, Kuipers B, Tommassen J, van der Ley P. Geurtsen J, et al. Among authors: hamstra hj. Infect Immun. 2006 Oct;74(10):5574-85. doi: 10.1128/IAI.00834-06. Infect Immun. 2006. PMID: 16988232 Free PMC article.

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Identification of a novel lipopolysaccharide core biosynthesis gene cluster in Bordetella pertussis, and influence of core structure and lipid A glucosamine substitution on endotoxic activity.

Geurtsen J, Dzieciatkowska M, Steeghs L, Hamstra HJ, Boleij J, Broen K, Akkerman G, El Hassan H, Li J, Richards JC, Tommassen J, van der Ley P. Geurtsen J, et al. Among authors: hamstra hj. Infect Immun. 2009 Jul;77(7):2602-11. doi: 10.1128/IAI.00033-09. Epub 2009 Apr 13. Infect Immun. 2009. PMID: 19364841 Free PMC article.

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Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy.

Fransen F, Heckenberg SG, Hamstra HJ, Feller M, Boog CJ, van Putten JP, van de Beek D, van der Ende A, van der Ley P. Fransen F, et al. Among authors: hamstra hj. PLoS Pathog. 2009 Apr;5(4):e1000396. doi: 10.1371/journal.ppat.1000396. Epub 2009 Apr 24. PLoS Pathog. 2009. PMID: 19390612 Free PMC article.

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Coincorporation of LpxL1 and PagL mutant lipopolysaccharides into liposomes with Neisseria meningitidis opacity protein: influence on endotoxic and adjuvant activity.

Arenas J, van Dijken H, Kuipers B, Hamstra HJ, Tommassen J, van der Ley P. Arenas J, et al. Among authors: hamstra hj. Clin Vaccine Immunol. 2010 Apr;17(4):487-95. doi: 10.1128/CVI.00423-09. Epub 2010 Jan 27. Clin Vaccine Immunol. 2010. PMID: 20107001 Free PMC article.

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Altered linkage of hydroxyacyl chains in lipid A of Campylobacter jejuni reduces TLR4 activation and antimicrobial resistance.

van Mourik A, Steeghs L, van Laar J, Meiring HD, Hamstra HJ, van Putten JP, Wösten MM. van Mourik A, et al. Among authors: hamstra hj. J Biol Chem. 2010 May 21;285(21):15828-36. doi: 10.1074/jbc.M110.102061. Epub 2010 Mar 29. J Biol Chem. 2010. PMID: 20351099 Free PMC article.

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Lipopolysaccharide engineering in Neisseria meningitidis: structural analysis of different pentaacyl lipid A mutants and comparison of their modified agonist properties.

Pupo E, Hamstra HJ, Meiring H, van der Ley P. Pupo E, et al. Among authors: hamstra hj. J Biol Chem. 2014 Mar 21;289(12):8668-80. doi: 10.1074/jbc.M114.554345. Epub 2014 Feb 3. J Biol Chem. 2014. PMID: 24492609 Free PMC article.

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Bordetella pertussis naturally occurring isolates with altered lipooligosaccharide structure fail to fully mature human dendritic cells.

Brummelman J, Veerman RE, Hamstra HJ, Deuss AJ, Schuijt TJ, Sloots A, Kuipers B, van Els CA, van der Ley P, Mooi FR, Han WG, Pinelli E. Brummelman J, et al. Among authors: hamstra hj. Infect Immun. 2015 Jan;83(1):227-38. doi: 10.1128/IAI.02197-14. Epub 2014 Oct 27. Infect Immun. 2015. PMID: 25348634 Free PMC article.

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Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells.

Hovingh ES, van Gent M, Hamstra HJ, Demkes M, Mooi FR, Pinelli E. Hovingh ES, et al. Among authors: hamstra hj. PLoS One. 2017 Jan 11;12(1):e0170027. doi: 10.1371/journal.pone.0170027. eCollection 2017. PLoS One. 2017. PMID: 28076445 Free PMC article.

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Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor.

Hovingh ES, Mariman R, Solans L, Hijdra D, Hamstra HJ, Jongerius I, van Gent M, Mooi F, Locht C, Pinelli E. Hovingh ES, et al. Among authors: hamstra hj. Emerg Microbes Infect. 2018 Mar 21;7(1):39. doi: 10.1038/s41426-018-0039-8. Emerg Microbes Infect. 2018. PMID: 29559630 Free PMC article.

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