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Artemisolide is a typical inhibitor of IkappaB kinase beta targeting cysteine-179 residue and down-regulates NF-kappaB-dependent TNF-alpha expression in LPS-activated macrophages.
Kim BH, Lee JY, Seo JH, Lee HY, Ryu SY, Ahn BW, Lee CK, Hwang BY, Han SB, Kim Y. Kim BH, et al. Among authors: Han SB. Biochem Biophys Res Commun. 2007 Sep 28;361(3):593-8. doi: 10.1016/j.bbrc.2007.07.069. Epub 2007 Jul 24. Biochem Biophys Res Commun. 2007. PMID: 17669364
Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta.
Kim BH, Roh E, Lee HY, Lee IJ, Ahn B, Jung SH, Lee H, Han SB, Kim Y. Kim BH, et al. Among authors: Han SB. Mol Pharmacol. 2008 Apr;73(4):1309-18. doi: 10.1124/mol.107.041251. Epub 2008 Jan 17. Mol Pharmacol. 2008. PMID: 18202307
Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of DNA binding ability of nuclear factor-kappaB in macrophages.
Kim BH, Hong SS, Kwon SW, Lee HY, Sung H, Lee IJ, Hwang BY, Song S, Lee CK, Chung D, Ahn B, Nam SY, Han SB, Kim Y. Kim BH, et al. Among authors: Han SB. J Pharmacol Exp Ther. 2008 Nov;327(2):393-401. doi: 10.1124/jpet.108.140145. Epub 2008 Aug 11. J Pharmacol Exp Ther. 2008. PMID: 18694995
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