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Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1alpha is dominant negative.
Yamagata K, Yang Q, Yamamoto K, Iwahashi H, Miyagawa J, Okita K, Yoshiuchi I, Miyazaki J, Noguchi T, Nakajima H, Namba M, Hanafusa T, Matsuzawa Y. Yamagata K, et al. Diabetes. 1998 Aug;47(8):1231-5. doi: 10.2337/diab.47.8.1231. Diabetes. 1998. PMID: 9703322
Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization.
Yoshiuchi I, Yamagata K, Yang Q, Iwahashi H, Okita K, Yamamoto K, Oue T, Imagawa A, Hamaguchi T, Yamasaki T, Horikawa Y, Satoh T, Nakajima H, Miyazaki J, Higashiyama S, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y. Yoshiuchi I, et al. Diabetologia. 1999 May;42(5):621-6. doi: 10.1007/s001250051204. Diabetologia. 1999. PMID: 10333057
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y. Hotta K, et al. Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1595-9. doi: 10.1161/01.atv.20.6.1595. Arterioscler Thromb Vasc Biol. 2000. PMID: 10845877
Identification of missense mutations in the hepatocyte nuclear factor-3beta gene in Japanese subjects with late-onset Type II diabetes mellitus.
Zhu Q, Yamagata K, Yu L, Tomura H, Yamada S, Yang Q, Yoshiuchi I, Sumi S, Miyagawa J, Takeda J, Hanafusa T, Matsuzawa Y. Zhu Q, et al. Diabetologia. 2000 Sep;43(9):1197-200. doi: 10.1007/s001250051512. Diabetologia. 2000. PMID: 11043867
Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-alpha in patients with recent-onset type 1 diabetes.
Uno S, Imagawa A, Okita K, Sayama K, Moriwaki M, Iwahashi H, Yamagata K, Tamura S, Matsuzawa Y, Hanafusa T, Miyagawa J, Shimomura I. Uno S, et al. Diabetologia. 2007 Mar;50(3):596-601. doi: 10.1007/s00125-006-0569-9. Epub 2007 Jan 13. Diabetologia. 2007. PMID: 17221211
We examined the involvement of TNF-alpha and IL-1beta, as well as of T cells, macrophages and dendritic cells, in the destruction of beta cells in patients with recent-onset type 1 diabetes. ...TNF-alpha was detected in 25.0 (4.3-46.9)% of macrophages and 11.8 (0-40.0)% of …
We examined the involvement of TNF-alpha and IL-1beta, as well as of T cells, macrophages and dendritic cells, in the destruction of …
Pancreatic beta and alpha cells are both decreased in patients with fulminant type 1 diabetes: a morphometrical assessment.
Sayama K, Imagawa A, Okita K, Uno S, Moriwaki M, Kozawa J, Iwahashi H, Yamagata K, Tamura S, Matsuzawa Y, Hanafusa T, Miyagawa J, Shimomura I. Sayama K, et al. Diabetologia. 2005 Aug;48(8):1560-4. doi: 10.1007/s00125-005-1829-9. Epub 2005 Jul 1. Diabetologia. 2005. PMID: 15991022
Analysis of a non-functional HNF-1alpha (TCF1) mutation in Japanese subjects with familial type 1 diabetes.
Yoshiuchi I, Yamagata K, Yoshimoto M, Zhu Q, Yang Q, Nammo T, Uenaka R, Kinoshita E, Hanafusa T, Miyagawa Ji, Matsuzawa Y. Yoshiuchi I, et al. Hum Mutat. 2001 Oct;18(4):345-51. doi: 10.1002/humu.1196. Hum Mutat. 2001. PMID: 11668618
Mutation screening of the hepatocyte nuclear factor (HNF)-6 gene in Japanese subjects with diabetes mellitus.
Zhu Q, Yamagata K, Tsukahara Y, Yang Q, Liu W, Hanafusa T, Miyagawa J, Matsuzawa Y. Zhu Q, et al. Diabetes Res Clin Pract. 2001 Jun;52(3):171-4. doi: 10.1016/s0168-8227(01)00222-4. Diabetes Res Clin Pract. 2001. PMID: 11323086
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