Hancock D - Search Results

1

Role of Bim in the survival pathway induced by Raf in epithelial cells.

Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR. Marani M, et al. Among authors: hancock d. Oncogene. 2004 Apr 1;23(14):2431-41. doi: 10.1038/sj.onc.1207364. Oncogene. 2004. PMID: 14676826

2

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

Marani M, Tenev T, Hancock D, Downward J, Lemoine NR. Marani M, et al. Among authors: hancock d. Mol Cell Biol. 2002 Jun;22(11):3577-89. doi: 10.1128/MCB.22.11.3577-3589.2002. Mol Cell Biol. 2002. PMID: 11997495 Free PMC article.

3

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.

Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC. Nicke B, et al. Mol Cell. 2005 Dec 9;20(5):673-85. doi: 10.1016/j.molcel.2005.10.038. Mol Cell. 2005. PMID: 16337592 Free article.

4

Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer.

Molina-Arcas M, Hancock DC, Sheridan C, Kumar MS, Downward J. Molina-Arcas M, et al. Cancer Discov. 2013 May;3(5):548-63. doi: 10.1158/2159-8290.CD-12-0446. Epub 2013 Mar 1. Cancer Discov. 2013. PMID: 23454899 Free PMC article.

5

c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner.

Iaccarino I, Hancock D, Evan G, Downward J. Iaccarino I, et al. Among authors: hancock d. Cell Death Differ. 2003 May;10(5):599-608. doi: 10.1038/sj.cdd.4401211. Cell Death Differ. 2003. PMID: 12728258

6

RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma.

East P, Kelly GP, Biswas D, Marani M, Hancock DC, Creasy T, Sachsenmeier K, Swanton C; TRACERx consortium; Downward J, de Carné Trécesson S. East P, et al. Among authors: hancock dc. Nat Commun. 2022 Sep 26;13(1):5632. doi: 10.1038/s41467-022-33290-0. Nat Commun. 2022. PMID: 36163168 Free PMC article.

7

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.

Steckel M, Molina-Arcas M, Weigelt B, Marani M, Warne PH, Kuznetsov H, Kelly G, Saunders B, Howell M, Downward J, Hancock DC. Steckel M, et al. Cell Res. 2012 Aug;22(8):1227-45. doi: 10.1038/cr.2012.82. Epub 2012 May 22. Cell Res. 2012. PMID: 22613949 Free PMC article.

8

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.

Wang Y, Bu F, Royer C, Serres S, Larkin JR, Soto MS, Sibson NR, Salter V, Fritzsche F, Turnquist C, Koch S, Zak J, Zhong S, Wu G, Liang A, Olofsen PA, Moch H, Hancock DC, Downward J, Goldin RD, Zhao J, Tong X, Guo Y, Lu X. Wang Y, et al. Among authors: hancock dc. Nat Cell Biol. 2014 Nov;16(11):1092-104. doi: 10.1038/ncb3050. Epub 2014 Oct 26. Nat Cell Biol. 2014. PMID: 25344754

9

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer.

Molina-Arcas M, Moore C, Rana S, van Maldegem F, Mugarza E, Romero-Clavijo P, Herbert E, Horswell S, Li LS, Janes MR, Hancock DC, Downward J. Molina-Arcas M, et al. Sci Transl Med. 2019 Sep 18;11(510):eaaw7999. doi: 10.1126/scitranslmed.aaw7999. Sci Transl Med. 2019. PMID: 31534020 Free PMC article.

10

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.

Kumar MS, Hancock DC, Molina-Arcas M, Steckel M, East P, Diefenbacher M, Armenteros-Monterroso E, Lassailly F, Matthews N, Nye E, Stamp G, Behrens A, Downward J. Kumar MS, et al. Cell. 2012 Apr 27;149(3):642-55. doi: 10.1016/j.cell.2012.02.059. Cell. 2012. PMID: 22541434 Free article.

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