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Creeping baselines and adaptive resistance to antibiotics.
Fernández L, Breidenstein EB, Hancock RE. Fernández L, et al. Drug Resist Updat. 2011 Feb;14(1):1-21. doi: 10.1016/j.drup.2011.01.001. Epub 2011 Feb 1. Drug Resist Updat. 2011. PMID: 21288762 Review.
Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli.
Patrzykat A, Friedrich CL, Zhang L, Mendoza V, Hancock RE. Patrzykat A, et al. Antimicrob Agents Chemother. 2002 Mar;46(3):605-14. doi: 10.1128/aac.46.3.605-614.2002. Antimicrob Agents Chemother. 2002. PMID: 11850238 Free PMC article.
Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa.
Hirakata Y, Srikumar R, Poole K, Gotoh N, Suematsu T, Kohno S, Kamihira S, Hancock RE, Speert DP. Hirakata Y, et al. J Exp Med. 2002 Jul 1;196(1):109-18. doi: 10.1084/jem.20020005. J Exp Med. 2002. PMID: 12093875 Free PMC article.
Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes.
Boehr DD, Draker KA, Koteva K, Bains M, Hancock RE, Wright GD. Boehr DD, et al. Chem Biol. 2003 Feb;10(2):189-96. doi: 10.1016/s1074-5521(03)00026-7. Chem Biol. 2003. PMID: 12618191
Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa.
McPhee JB, Lewenza S, Hancock RE. McPhee JB, et al. Mol Microbiol. 2003 Oct;50(1):205-17. doi: 10.1046/j.1365-2958.2003.03673.x. Mol Microbiol. 2003. PMID: 14507375
Concerns regarding resistance to self-proteins.
Hancock REW. Hancock REW. Microbiology (Reading). 2003 Dec;149(Pt 12):3343-3344. doi: 10.1099/mic.0.C0122-0. Microbiology (Reading). 2003. PMID: 14663066 No abstract available.
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