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423 results

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Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism.
Collin de l'Hortet A, Takeishi K, Guzman-Lepe J, Morita K, Achreja A, Popovic B, Wang Y, Handa K, Mittal A, Meurs N, Zhu Z, Weinberg F, Salomon M, Fox IJ, Deng CX, Nagrath D, Soto-Gutierrez A. Collin de l'Hortet A, et al. Among authors: handa k. Cell Metab. 2019 Aug 6;30(2):385-401.e9. doi: 10.1016/j.cmet.2019.06.017. Cell Metab. 2019. PMID: 31390551 Free PMC article.
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.
Takeishi K, Collin de l'Hortet A, Wang Y, Handa K, Guzman-Lepe J, Matsubara K, Morita K, Jang S, Haep N, Florentino RM, Yuan F, Fukumitsu K, Tobita K, Sun W, Franks J, Delgado ER, Shapiro EM, Fraunhoffer NA, Duncan AW, Yagi H, Mashimo T, Fox IJ, Soto-Gutierrez A. Takeishi K, et al. Among authors: handa k. Cell Rep. 2020 Jun 2;31(9):107711. doi: 10.1016/j.celrep.2020.107711. Cell Rep. 2020. PMID: 32492423 Free PMC article.
Assembly of human organs from stem cells to study liver disease.
Handa K, Matsubara K, Fukumitsu K, Guzman-Lepe J, Watson A, Soto-Gutierrez A. Handa K, et al. Am J Pathol. 2014 Feb;184(2):348-57. doi: 10.1016/j.ajpath.2013.11.003. Epub 2013 Dec 12. Am J Pathol. 2014. PMID: 24333262 Free PMC article. Review.
Liver-Regenerative Transplantation: Regrow and Reset.
Collin de l'Hortet A, Takeishi K, Guzman-Lepe J, Handa K, Matsubara K, Fukumitsu K, Dorko K, Presnell SC, Yagi H, Soto-Gutierrez A. Collin de l'Hortet A, et al. Among authors: handa k. Am J Transplant. 2016 Jun;16(6):1688-96. doi: 10.1111/ajt.13678. Epub 2016 Feb 18. Am J Transplant. 2016. PMID: 26699680 Free PMC article. Review.
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Nishikawa T, Bellance N, Damm A, Bing H, Zhu Z, Handa K, Yovchev MI, Sehgal V, Moss TJ, Oertel M, Ram PT, Pipinos II, Soto-Gutierrez A, Fox IJ, Nagrath D. Nishikawa T, et al. Among authors: handa k. J Hepatol. 2014 Jun;60(6):1203-11. doi: 10.1016/j.jhep.2014.02.014. Epub 2014 Feb 26. J Hepatol. 2014. PMID: 24583248 Free PMC article.
Resetting the transcription factor network reverses terminal chronic hepatic failure.
Nishikawa T, Bell A, Brooks JM, Setoyama K, Melis M, Han B, Fukumitsu K, Handa K, Tian J, Kaestner KH, Vodovotz Y, Locker J, Soto-Gutierrez A, Fox IJ. Nishikawa T, et al. Among authors: handa k. J Clin Invest. 2015 Apr;125(4):1533-44. doi: 10.1172/JCI73137. Epub 2015 Mar 16. J Clin Invest. 2015. PMID: 25774505 Free PMC article.
Postoperative Delirium in Patients after Pancreaticoduodenectomy.
Ito Y, Abe Y, Handa K, Shibutani S, Egawa T, Nagashima A, Kitago M, Itano O, Kitagawa Y. Ito Y, et al. Among authors: handa k. Dig Surg. 2017;34(1):78-85. doi: 10.1159/000446928. Epub 2016 Jul 28. Dig Surg. 2017. PMID: 27463247
423 results