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A primatized MAb to human CD4 causes receptor modulation, without marked reduction in CD4+ T cells in chimpanzees: in vitro and in vivo characterization of a MAb (IDEC-CE9.1) to human CD4.
Anderson D, Chambers K, Hanna N, Leonard J, Reff M, Newman R, Baldoni J, Dunleavy D, Reddy M, Sweet R, Truneh A. Anderson D, et al. Among authors: hanna n. Clin Immunol Immunopathol. 1997 Jul;84(1):73-84. doi: 10.1006/clin.1997.4363. Clin Immunol Immunopathol. 1997. PMID: 9191886
Modification of the Fc region of a primatized IgG antibody to human CD4 retains its ability to modulate CD4 receptors but does not deplete CD4(+) T cells in chimpanzees.
Newman R, Hariharan K, Reff M, Anderson DR, Braslawsky G, Santoro D, Hanna N, Bugelski PJ, Brigham-Burke M, Crysler C, Gagnon RC, Dal Monte P, Doyle ML, Hensley PC, Reddy MP, Sweet RW, Truneh A. Newman R, et al. Among authors: hanna n. Clin Immunol. 2001 Feb;98(2):164-74. doi: 10.1006/clim.2000.4975. Clin Immunol. 2001. PMID: 11161972
Antibody therapy of non-Hodgkin's B-cell lymphoma.
Chinn P, Braslawsky G, White C, Hanna N. Chinn P, et al. Among authors: hanna n. Cancer Immunol Immunother. 2003 May;52(5):257-80. doi: 10.1007/s00262-002-0347-6. Epub 2003 Feb 28. Cancer Immunol Immunother. 2003. PMID: 12700943 Review.
Future approaches for treating hematologic disease.
Reff M, Braslawsky G, Hanna N. Reff M, et al. Among authors: hanna n. Curr Pharm Biotechnol. 2001 Dec;2(4):369-82. doi: 10.2174/1389201013378626. Curr Pharm Biotechnol. 2001. PMID: 11762418 Review.
768 results