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Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time.
Feichtinger J, Hernández I, Fischer C, Hanscho M, Auer N, Hackl M, Jadhav V, Baumann M, Krempl PM, Schmidl C, Farlik M, Schuster M, Merkel A, Sommer A, Heath S, Rico D, Bock C, Thallinger GG, Borth N. Feichtinger J, et al. Among authors: hanscho m. Biotechnol Bioeng. 2016 Oct;113(10):2241-53. doi: 10.1002/bit.25990. Epub 2016 Apr 29. Biotechnol Bioeng. 2016. PMID: 27072894 Free PMC article.
Epigenetic regulation of gene expression in Chinese Hamster Ovary cells in response to the changing environment of a batch culture.
Hernandez I, Dhiman H, Klanert G, Jadhav V, Auer N, Hanscho M, Baumann M, Esteve-Codina A, Dabad M, Gómez J, Alioto T, Merkel A, Raineri E, Heath S, Rico D, Borth N. Hernandez I, et al. Among authors: hanscho m. Biotechnol Bioeng. 2019 Mar;116(3):677-692. doi: 10.1002/bit.26891. Epub 2019 Jan 4. Biotechnol Bioeng. 2019. PMID: 30512195 Free PMC article.
What can mathematical modelling say about CHO metabolism and protein glycosylation?
Galleguillos SN, Ruckerbauer D, Gerstl MP, Borth N, Hanscho M, Zanghellini J. Galleguillos SN, et al. Among authors: hanscho m. Comput Struct Biotechnol J. 2017 Jan 28;15:212-221. doi: 10.1016/j.csbj.2017.01.005. eCollection 2017. Comput Struct Biotechnol J. 2017. PMID: 28228925 Free PMC article. Review.
What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines.
Széliová D, Ruckerbauer DE, Galleguillos SN, Petersen LB, Natter K, Hanscho M, Troyer C, Causon T, Schoeny H, Christensen HB, Lee DY, Lewis NE, Koellensperger G, Hann S, Nielsen LK, Borth N, Zanghellini J. Széliová D, et al. Among authors: hanscho m. Metab Eng. 2020 Sep;61:288-300. doi: 10.1016/j.ymben.2020.06.002. Epub 2020 Jun 30. Metab Eng. 2020. PMID: 32619503 Free article.
Inclusion of maintenance energy improves the intracellular flux predictions of CHO.
Széliová D, Štor J, Thiel I, Weinguny M, Hanscho M, Lhota G, Borth N, Zanghellini J, Ruckerbauer DE, Rocha I. Széliová D, et al. Among authors: hanscho m. PLoS Comput Biol. 2021 Jun 11;17(6):e1009022. doi: 10.1371/journal.pcbi.1009022. eCollection 2021 Jun. PLoS Comput Biol. 2021. PMID: 34115746 Free PMC article.
A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.
Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, Wulff T, Arnsdorf J, Li S, Lee JS, Paglia G, Loira N, Spahn PN, Pedersen LE, Gutierrez JM, King ZA, Lund AM, Nagarajan H, Thomas A, Abdel-Haleem AM, Zanghellini J, Kildegaard HF, Voldborg BG, Gerdtzen ZP, Betenbaugh MJ, Palsson BO, Andersen MR, Nielsen LK, Borth N, Lee DY, Lewis NE. Hefzi H, et al. Among authors: hanscho m. Cell Syst. 2016 Nov 23;3(5):434-443.e8. doi: 10.1016/j.cels.2016.10.020. Cell Syst. 2016. PMID: 27883890 Free PMC article.
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