Hansell E - Search Results

1

A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.

Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. Brinen LS, et al. Among authors: hansell e. Structure. 2000 Aug 15;8(8):831-40. doi: 10.1016/s0969-2126(00)00173-8. Structure. 2000. PMID: 10997902 Free article.

2

Aryl ureas represent a new class of anti-trypanosomal agents.

Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. Du X, et al. Among authors: hansell e. Chem Biol. 2000 Sep;7(9):733-42. doi: 10.1016/s1074-5521(00)00018-1. Chem Biol. 2000. PMID: 10980453

3

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.

Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL 2nd, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. Caffrey CR, et al. Among authors: hansell e. Mol Biochem Parasitol. 2001 Nov;118(1):61-73. doi: 10.1016/s0166-6851(01)00368-1. Mol Biochem Parasitol. 2001. PMID: 11704274

4

Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model.

Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL Jr, Reed SL. Meléndez-López SG, et al. Among authors: hansell e. Eukaryot Cell. 2007 Jul;6(7):1130-6. doi: 10.1128/EC.00094-07. Epub 2007 May 18. Eukaryot Cell. 2007. PMID: 17513563 Free PMC article.

5

Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model.

Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA. Bok RA, et al. Among authors: hansell ej. Prostate Cancer Prostatic Dis. 2003;6(4):272-80. doi: 10.1038/sj.pcan.4500676. Prostate Cancer Prostatic Dis. 2003. PMID: 14663466

6

Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain.

Roush WR, González FV, McKerrow JH, Hansell E. Roush WR, et al. Among authors: hansell e. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2809-12. doi: 10.1016/s0960-894x(98)00494-6. Bioorg Med Chem Lett. 1998. PMID: 9873627

7

Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.

Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ. Scheidt KA, et al. Among authors: hansell e. Bioorg Med Chem. 1998 Dec;6(12):2477-94. doi: 10.1016/s0968-0896(98)80022-9. Bioorg Med Chem. 1998. PMID: 9925304

8

Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease.

Salter JP, Lim KC, Hansell E, Hsieh I, McKerrow JH. Salter JP, et al. Among authors: hansell e. J Biol Chem. 2000 Dec 8;275(49):38667-73. doi: 10.1074/jbc.M006997200. J Biol Chem. 2000. PMID: 10993899 Free article.

9

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.

Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC. Roush WR, et al. Among authors: hansell e. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2759-62. doi: 10.1016/s0960-894x(01)00566-2. Bioorg Med Chem Lett. 2001. PMID: 11591518

10

Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus.

Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS. Goetz DH, et al. Among authors: hansell e. Biochemistry. 2007 Jul 31;46(30):8744-52. doi: 10.1021/bi0621415. Epub 2007 Jul 3. Biochemistry. 2007. PMID: 17605471

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