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Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes.
Mandøe MJ, Hansen KB, Windeløv JA, Knop FK, Rehfeld JF, Rosenkilde MM, Holst JJ, Hansen HS. Mandøe MJ, et al. Among authors: hansen kb, hansen hs. Nutr Diabetes. 2018 Jan 12;8(1):2. doi: 10.1038/s41387-017-0011-z. Nutr Diabetes. 2018. PMID: 29330461 Free PMC article. Clinical Trial.
2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.
Hansen KB, Rosenkilde MM, Knop FK, Wellner N, Diep TA, Rehfeld JF, Andersen UB, Holst JJ, Hansen HS. Hansen KB, et al. Among authors: hansen hs. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17. doi: 10.1210/jc.2011-0647. Epub 2011 Jul 21. J Clin Endocrinol Metab. 2011. PMID: 21778222
GPR119 as a fat sensor.
Hansen HS, Rosenkilde MM, Holst JJ, Schwartz TW. Hansen HS, et al. Trends Pharmacol Sci. 2012 Jul;33(7):374-81. doi: 10.1016/j.tips.2012.03.014. Epub 2012 May 2. Trends Pharmacol Sci. 2012. PMID: 22560300 Review.
429 results