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Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema.
Stanley SE, Gable DL, Wagner CL, Carlile TM, Hanumanthu VS, Podlevsky JD, Khalil SE, DeZern AE, Rojas-Duran MF, Applegate CD, Alder JK, Parry EM, Gilbert WV, Armanios M. Stanley SE, et al. Among authors: hanumanthu vs. Sci Transl Med. 2016 Aug 10;8(351):351ra107. doi: 10.1126/scitranslmed.aaf7837. Sci Transl Med. 2016. PMID: 27510903 Free PMC article.
Diagnostic utility of telomere length testing in a hospital-based setting.
Alder JK, Hanumanthu VS, Strong MA, DeZern AE, Stanley SE, Takemoto CM, Danilova L, Applegate CD, Bolton SG, Mohr DW, Brodsky RA, Casella JF, Greider CW, Jackson JB, Armanios M. Alder JK, et al. Among authors: hanumanthu vs. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2358-E2365. doi: 10.1073/pnas.1720427115. Epub 2018 Feb 20. Proc Natl Acad Sci U S A. 2018. PMID: 29463756 Free PMC article.
Short telomere syndromes cause a primary T cell immunodeficiency.
Wagner CL, Hanumanthu VS, Talbot CC Jr, Abraham RS, Hamm D, Gable DL, Kanakry CG, Applegate CD, Siliciano J, Jackson JB, Desiderio S, Alder JK, Luznik L, Armanios M. Wagner CL, et al. Among authors: hanumanthu vs. J Clin Invest. 2018 Dec 3;128(12):5222-5234. doi: 10.1172/JCI120216. Epub 2018 Oct 22. J Clin Invest. 2018. PMID: 30179220 Free PMC article.
Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres.
Popescu I, Mannem H, Winters SA, Hoji A, Silveira F, McNally E, Pipeling MR, Lendermon EA, Morrell MR, Pilewski JM, Hanumanthu VS, Zhang Y, Gulati S, Shah PD, Iasella CJ, Ensor CR, Armanios M, McDyer JF. Popescu I, et al. Among authors: hanumanthu vs. Am J Respir Crit Care Med. 2019 Feb 1;199(3):362-376. doi: 10.1164/rccm.201805-0825OC. Am J Respir Crit Care Med. 2019. PMID: 30088779 Free PMC article.
IPF lung fibroblasts have a senescent phenotype.
Álvarez D, Cárdenes N, Sellarés J, Bueno M, Corey C, Hanumanthu VS, Peng Y, D'Cunha H, Sembrat J, Nouraie M, Shanker S, Caufield C, Shiva S, Armanios M, Mora AL, Rojas M. Álvarez D, et al. Among authors: hanumanthu vs. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1164-L1173. doi: 10.1152/ajplung.00220.2017. Epub 2017 Aug 31. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 28860144 Free PMC article.
Increased flux through the mevalonate pathway mediates fibrotic repair without injury.
Larson-Casey JL, Vaid M, Gu L, He C, Cai GQ, Ding Q, Davis D, Berryhill TF, Wilson LS, Barnes S, Neighbors JD, Hohl RJ, Zimmerman KA, Yoder BK, Longhini ALF, Hanumanthu VS, Surolia R, Antony VB, Carter AB. Larson-Casey JL, et al. Among authors: hanumanthu vs. J Clin Invest. 2019 Nov 1;129(11):4962-4978. doi: 10.1172/JCI127959. J Clin Invest. 2019. PMID: 31609245 Free PMC article.
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