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Targeted protein degradation: current and future challenges.
Curr Opin Chem Biol. 2020 Jun;56:35-41. doi: 10.1016/j.cbpa.2019.11.012. Epub 2020 Jan 2.
Curr Opin Chem Biol. 2020.
PMID: 31901786
Free PMC article.
Review.
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation.
Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE.
Mayor-Ruiz C, et al. Among authors: hanzl a.
Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013.
Mol Cell. 2019.
PMID: 31442425
Free article.
Item in Clipboard
Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells.
Ferreira da Silva J, Salic S, Wiedner M, Datlinger P, Essletzbichler P, Hanzl A, Superti-Furga G, Bock C, Winter G, Loizou JI.
Ferreira da Silva J, et al. Among authors: hanzl a.
Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9.
Sci Rep. 2019.
PMID: 31673055
Free PMC article.
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Selective Mediator dependence of cell-type-specifying transcription.
Jaeger MG, Schwalb B, Mackowiak SD, Velychko T, Hanzl A, Imrichova H, Brand M, Agerer B, Chorn S, Nabet B, Ferguson FM, Müller AC, Bergthaler A, Gray NS, Bradner JE, Bock C, Hnisz D, Cramer P, Winter GE.
Jaeger MG, et al. Among authors: hanzl a.
Nat Genet. 2020 Jul;52(7):719-727. doi: 10.1038/s41588-020-0635-0. Epub 2020 Jun 1.
Nat Genet. 2020.
PMID: 32483291
Free PMC article.
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E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance.
Hanzl A, Barone E, Bauer S, Yue H, Nowak RP, Hahn E, Pankevich EV, Koren A, Kubicek S, Fischer ES, Winter GE.
Hanzl A, et al.
J Am Chem Soc. 2023 Jan 18;145(2):1176-1184. doi: 10.1021/jacs.2c10784. Epub 2023 Jan 5.
J Am Chem Soc. 2023.
PMID: 36602777
Free PMC article.
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Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders.
Hanzl A, Casement R, Imrichova H, Hughes SJ, Barone E, Testa A, Bauer S, Wright J, Brand M, Ciulli A, Winter GE.
Hanzl A, et al.
Nat Chem Biol. 2023 Mar;19(3):323-333. doi: 10.1038/s41589-022-01177-2. Epub 2022 Nov 3.
Nat Chem Biol. 2023.
PMID: 36329119
Free PMC article.
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