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128 results
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Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine.
Shaffer CL, Harriman S, Koen YM, Hanzlik RP. Shaffer CL, et al. Among authors: hanzlik rp. J Am Chem Soc. 2002 Jul 17;124(28):8268-74. doi: 10.1021/ja0119346. J Am Chem Soc. 2002. PMID: 12105905
Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450.
Hall LR, Hanzlik RP. Hall LR, et al. Among authors: hanzlik rp. J Biol Chem. 1990 Jul 25;265(21):12349-55. J Biol Chem. 1990. PMID: 2373695
Electron transfer in P450 mechanisms. Microsomal metabolism of cyclopropylbenzene and p-cyclopropylanisole.
Riley P, Hanzlik RP. Riley P, et al. Among authors: hanzlik rp. Xenobiotica. 1994 Jan;24(1):1-16. doi: 10.3109/00498259409043216. Xenobiotica. 1994. PMID: 8165817
N-dealkylation of tertiary amides by cytochrome P-450.
Hall LR, Hanzlik RP. Hall LR, et al. Among authors: hanzlik rp. Xenobiotica. 1991 Sep;21(9):1127-38. doi: 10.3109/00498259109039553. Xenobiotica. 1991. PMID: 1788981
Comparative Toxicity and Metabolism of N-Acyl Homologues of Acetaminophen and Its Isomer 3'-Hydroxyacetanilide.
Koen YM, Liu K, Shinogle H, Williams TD, Hanzlik RP. Koen YM, et al. Among authors: hanzlik rp. Chem Res Toxicol. 2016 Nov 21;29(11):1857-1864. doi: 10.1021/acs.chemrestox.6b00270. Epub 2016 Oct 13. Chem Res Toxicol. 2016. PMID: 27680534
Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes.
Cerny MA, Hanzlik RP. Cerny MA, et al. Among authors: hanzlik rp. Arch Biochem Biophys. 2005 Apr 15;436(2):265-75. doi: 10.1016/j.abb.2005.02.020. Arch Biochem Biophys. 2005. PMID: 15797239
Hydroxylation of fatty acids by microsomal and reconstituted cytochrome P450 2B1.
Alterman MA, Hanzlik RP. Alterman MA, et al. Among authors: hanzlik rp. FEBS Lett. 2002 Feb 13;512(1-3):319-22. doi: 10.1016/s0014-5793(02)02260-3. FEBS Lett. 2002. PMID: 11852103
Synthesis of N tau-arylhistidine derivatives via direct N-arylation.
Yue W, Lewis SI, Koen YM, Hanzlik RP. Yue W, et al. Among authors: hanzlik rp. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1637-40. doi: 10.1016/j.bmcl.2004.01.058. Bioorg Med Chem Lett. 2004. PMID: 15026040
Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo.
Ikehata K, Duzhak TG, Galeva NA, Ji T, Koen YM, Hanzlik RP. Ikehata K, et al. Among authors: hanzlik rp. Chem Res Toxicol. 2008 Jul;21(7):1432-42. doi: 10.1021/tx800093k. Epub 2008 Jun 12. Chem Res Toxicol. 2008. PMID: 18547066 Free PMC article.
A proteomic analysis of bromobenzene reactive metabolite targets in rat liver cytosol in vivo.
Koen YM, Gogichaeva NV, Alterman MA, Hanzlik RP. Koen YM, et al. Among authors: hanzlik rp. Chem Res Toxicol. 2007 Mar;20(3):511-9. doi: 10.1021/tx6003166. Epub 2007 Feb 17. Chem Res Toxicol. 2007. PMID: 17305373
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