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The significance of elevated beta 2-microglobulin (b2-m) in chronic lymphocytic leukemia (CLL): Evidence of in vitro secretion following activation of CLL cells.
Berrebi A, Bassous L, Haran M, Shtalrid M, Shvidel L. Berrebi A, et al. Leuk Res. 2010 Sep;34(9):e248-9. doi: 10.1016/j.leukres.2010.03.027. Epub 2010 Apr 14. Leuk Res. 2010. PMID: 20392494 No abstract available.
TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner.
Binsky I, Lantner F, Grabovsky V, Harpaz N, Shvidel L, Berrebi A, Goldenberg DM, Leng L, Bucala R, Alon R, Haran M, Shachar I. Binsky I, et al. J Immunol. 2010 May 1;184(9):4761-9. doi: 10.4049/jimmunol.0904149. Epub 2010 Mar 31. J Immunol. 2010. PMID: 20357260 Free PMC article.
A phase I-II clinical trial of the anti-CD74 monoclonal antibody milatuzumab in frail patients with refractory chronic lymphocytic leukaemia: A patient based approach.
Haran M, Mirkin V, Braester A, Harpaz N, Shevetz O, Shtreiter M, Greenberg S, Mordich O, Amram O, Binsky-Ehrenreich I, Marom A, Shachar I, Herishanu Y, Ruchlemer R, Berrebi A, Valinsky L, Shtalrid M, Shvidel L. Haran M, et al. Br J Haematol. 2018 Jul;182(1):125-128. doi: 10.1111/bjh.14726. Epub 2017 May 3. Br J Haematol. 2018. PMID: 28466956 Clinical Trial. No abstract available.
The cytokine midkine and its receptor RPTPĪ¶ regulate B cell survival in a pathway induced by CD74.
Cohen S, Shoshana OY, Zelman-Toister E, Maharshak N, Binsky-Ehrenreich I, Gordin M, Hazan-Halevy I, Herishanu Y, Shvidel L, Haran M, Leng L, Bucala R, Harroch S, Shachar I. Cohen S, et al. J Immunol. 2012 Jan 1;188(1):259-69. doi: 10.4049/jimmunol.1101468. Epub 2011 Dec 2. J Immunol. 2012. PMID: 22140262 Free PMC article.
IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival.
Binsky I, Haran M, Starlets D, Gore Y, Lantner F, Harpaz N, Leng L, Goldenberg DM, Shvidel L, Berrebi A, Bucala R, Shachar I. Binsky I, et al. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13408-13. doi: 10.1073/pnas.0701553104. Epub 2007 Aug 8. Proc Natl Acad Sci U S A. 2007. PMID: 17686984 Free PMC article.
Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival.
Starlets D, Gore Y, Binsky I, Haran M, Harpaz N, Shvidel L, Becker-Herman S, Berrebi A, Shachar I. Starlets D, et al. Blood. 2006 Jun 15;107(12):4807-16. doi: 10.1182/blood-2005-11-4334. Epub 2006 Feb 16. Blood. 2006. PMID: 16484589
CD84 mediates CLL-microenvironment interactions.
Marom A, Barak AF, Kramer MP, Lewinsky H, Binsky-Ehrenreich I, Cohen S, Tsitsou-Kampeli A, Kalchenko V, Kuznetsov Y, Mirkin V, Dezorella N, Shapiro M, Schwartzberg PL, Cohen Y, Shvidel L, Haran M, Becker-Herman S, Herishanu Y, Shachar I. Marom A, et al. Oncogene. 2017 Feb 2;36(5):628-638. doi: 10.1038/onc.2016.238. Epub 2016 Jul 25. Oncogene. 2017. PMID: 27452524
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