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Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Harb H, Benamar M, Lai PS, Contini P, Griffith JW, Crestani E, Schmitz-Abe K, Chen Q, Fong J, Marri L, Filaci G, Del Zotto G, Pishesha N, Kolifrath S, Broggi A, Ghosh S, Gelmez MY, Oktelik FB, Cetin EA, Kiykim A, Kose M, Wang Z, Cui Y, Yu XG, Li JZ, Berra L, Stephen-Victor E, Charbonnier LM, Zanoni I, Ploegh H, Deniz G, De Palma R, Chatila TA. Harb H, et al. Immunity. 2021 Jun 8;54(6):1186-1199.e7. doi: 10.1016/j.immuni.2021.04.002. Epub 2021 Apr 28. Immunity. 2021. PMID: 33915108 Free PMC article.
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
Tachdjian R, Mathias C, Al Khatib S, Bryce PJ, Kim HS, Blaeser F, O'Connor BD, Rzymkiewicz D, Chen A, Holtzman MJ, Hershey GK, Garn H, Harb H, Renz H, Oettgen HC, Chatila TA. Tachdjian R, et al. Among authors: harb h. J Exp Med. 2009 Sep 28;206(10):2191-204. doi: 10.1084/jem.20091480. Epub 2009 Sep 21. J Exp Med. 2009. PMID: 19770271 Free PMC article.
Treatment of severe persistent asthma with IL-6 receptor blockade.
Esty B, Harb H, Bartnikas LM, Charbonnier LM, Massoud AH, Leon-Astudillo C, Visner G, Subramaniam M, Phipatanakul W, Chatila TA. Esty B, et al. Among authors: harb h. J Allergy Clin Immunol Pract. 2019 May-Jun;7(5):1639-1642.e4. doi: 10.1016/j.jaip.2019.02.043. Epub 2019 Mar 15. J Allergy Clin Immunol Pract. 2019. PMID: 30885880 Free PMC article. No abstract available.
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy.
Abdel-Gadir A, Stephen-Victor E, Gerber GK, Noval Rivas M, Wang S, Harb H, Wang L, Li N, Crestani E, Spielman S, Secor W, Biehl H, DiBenedetto N, Dong X, Umetsu DT, Bry L, Rachid R, Chatila TA. Abdel-Gadir A, et al. Among authors: harb h. Nat Med. 2019 Jul;25(7):1164-1174. doi: 10.1038/s41591-019-0461-z. Epub 2019 Jun 24. Nat Med. 2019. PMID: 31235962 Free PMC article.
Functional reprogramming of regulatory T cells in the absence of Foxp3.
Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, Garcia-Lloret MI, Chen K, Ozen A, Carmeliet P, Li MO, Pellegrini M, Chatila TA. Charbonnier LM, et al. Among authors: harb h. Nat Immunol. 2019 Sep;20(9):1208-1219. doi: 10.1038/s41590-019-0442-x. Epub 2019 Aug 5. Nat Immunol. 2019. PMID: 31384057 Free PMC article.
Mechanisms of Dupilumab.
Harb H, Chatila TA. Harb H, et al. Clin Exp Allergy. 2020 Jan;50(1):5-14. doi: 10.1111/cea.13491. Epub 2019 Sep 30. Clin Exp Allergy. 2020. PMID: 31505066 Free PMC article. Review.
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.
Harb H, Stephen-Victor E, Crestani E, Benamar M, Massoud A, Cui Y, Charbonnier LM, Arbag S, Baris S, Cunnigham A, Leyva-Castillo JM, Geha RS, Mousavi AJ, Guennewig B, Schmitz-Abe K, Sioutas C, Phipatanakul W, Chatila TA. Harb H, et al. Nat Immunol. 2020 Nov;21(11):1359-1370. doi: 10.1038/s41590-020-0777-3. Epub 2020 Sep 14. Nat Immunol. 2020. PMID: 32929274 Free PMC article.
191 results