The porcine hormone-sensitive lipase gene: sequence, structure, polymorphisms and linkage mapping

I Harbitz; M Langset; A G Ege; B Høyheim; W Davies

doi:10.1046/j.1365-2052.1999.00412.x

The porcine hormone-sensitive lipase gene: sequence, structure, polymorphisms and linkage mapping

Anim Genet. 1999 Feb;30(1):10-5. doi: 10.1046/j.1365-2052.1999.00412.x.

Authors

I Harbitz¹, M Langset, A G Ege, B Høyheim, W Davies

Affiliation

¹ Department of Biochemistry, Physiology and Nutrition, Norwegian School of Veterinary Science, Oslo, Norway.

PMID: 10050278
DOI: 10.1046/j.1365-2052.1999.00412.x

Abstract

The porcine hormone-sensitive lipase gene and its cDNA have been isolated and sequenced. Several putative regulatory sequences have been detected in the promotor region. The deduced amino acid sequence is 85% identical to the corresponding human, mouse and rat sequence. A search for polymorphisms revealed one intronic and one exonic polymorphism, the latter resulting in a conservative amino acid substitution. Linkage mapping located the LIPE gene close to the calcium release channel (CRC) locus on chromosome 6.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Chromosome Mapping / veterinary*
DNA, Complementary / chemistry
DNA, Complementary / isolation & purification
Gene Expression Regulation, Enzymologic
Gene Library
Genetic Variation
Humans
Introns
Mice
Molecular Sequence Data
Polymorphism, Genetic*
Rats
Restriction Mapping / veterinary
Sequence Alignment / veterinary
Sterol Esterase / genetics*
Swine

Substances

DNA, Complementary
Sterol Esterase

Associated data

GENBANK/AJ000482
GENBANK/AJ000483
GENBANK/AJ006075
GENBANK/AJ006076