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Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.
Maruoka H, Jayasekara MP, Barrett MO, Franklin DA, de Castro S, Kim N, Costanzi S, Harden TK, Jacobson KA. Maruoka H, et al. J Med Chem. 2011 Jun 23;54(12):4018-33. doi: 10.1021/jm101591j. Epub 2011 May 20. J Med Chem. 2011. PMID: 21528910 Free PMC article.
Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.
Houston D, Costanzi S, Jacobson KA, Harden TK. Houston D, et al. Comb Chem High Throughput Screen. 2008 Jul;11(6):410-9. doi: 10.2174/138620708784911474. Comb Chem High Throughput Screen. 2008. PMID: 18673269 Free PMC article. Review.
2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.
Kim HS, Ohno M, Xu B, Kim HO, Choi Y, Ji XD, Maddileti S, Marquez VE, Harden TK, Jacobson KA. Kim HS, et al. J Med Chem. 2003 Nov 6;46(23):4974-87. doi: 10.1021/jm030127+. J Med Chem. 2003. PMID: 14584948 Free PMC article.
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
Kim HS, Ravi RG, Marquez VE, Maddileti S, Wihlborg AK, Erlinge D, Malmsjö M, Boyer JL, Harden TK, Jacobson KA. Kim HS, et al. J Med Chem. 2002 Jan 3;45(1):208-18. doi: 10.1021/jm010369e. J Med Chem. 2002. PMID: 11754592 Free PMC article.
Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.
Ravi RG, Kim HS, Servos J, Zimmermann H, Lee K, Maddileti S, Boyer JL, Harden TK, Jacobson KA. Ravi RG, et al. J Med Chem. 2002 May 9;45(10):2090-100. doi: 10.1021/jm010538v. J Med Chem. 2002. PMID: 11985476 Free PMC article.
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