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Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation.
Harder T, Simons K. Harder T, et al. Eur J Immunol. 1999 Feb;29(2):556-62. doi: 10.1002/(SICI)1521-4141(199902)29:02<556::AID-IMMU556>3.0.CO;2-2. Eur J Immunol. 1999. PMID: 10064071
We have studied cellular responses to raft patch formation in the Jurkat T cell line and in particular changes in the actin cytoskeleton. ...
We have studied cellular responses to raft patch formation in the Jurkat T cell line and in particular changes in the actin cytoskele …
T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.
Stirnweiss A, Hartig R, Gieseler S, Lindquist JA, Reichardt P, Philipsen L, Simeoni L, Poltorak M, Merten C, Zuschratter W, Prokazov Y, Paster W, Stockinger H, Harder T, Gunzer M, Schraven B. Stirnweiss A, et al. Among authors: harder t. Sci Signal. 2013 Feb 19;6(263):ra13. doi: 10.1126/scisignal.2003607. Sci Signal. 2013. PMID: 23423439
The lymphocyte-specific Src family protein tyrosine kinase p56(Lck) (Lck) is essential for T cell development and activation and, hence, for adaptive immune responses. The mechanism by which Lck activity is directed toward specific substrates in response to T cell r …
The lymphocyte-specific Src family protein tyrosine kinase p56(Lck) (Lck) is essential for T cell development and activation and, hen …
Lipid raft domains and protein networks in T-cell receptor signal transduction.
Harder T. Harder T. Curr Opin Immunol. 2004 Jun;16(3):353-9. doi: 10.1016/j.coi.2004.03.013. Curr Opin Immunol. 2004. PMID: 15134785 Review.
Activation of the T-cell antigen receptor (TCR) is a key event in triggering the physiological responses of T lymphocytes to antigen. The earliest TCR-evoked signalling steps, such as tyrosine phosphorylations, ras activation and induction of Ca(2+) fluxes, are init …
Activation of the T-cell antigen receptor (TCR) is a key event in triggering the physiological responses of T lymphocytes to a …
Immunoisolation of TCR signaling complexes from Jurkat T leukemic cells.
Harder T, Kuhn M. Harder T, et al. Sci STKE. 2001 Feb 27;2001(71):pl1. doi: 10.1126/stke.2001.71.pl1. Sci STKE. 2001. PMID: 11752642
We have developed a method to immunoisolate activated T cell receptors (TCRs) and associated signaling molecules in plasma membrane subdomains from Jurkat T leukemic cells. ...
We have developed a method to immunoisolate activated T cell receptors (TCRs) and associated signaling molecules in plasma membrane s …
Raft membrane domains and immunoreceptor functions.
Harder T. Harder T. Adv Immunol. 2001;77:45-92. doi: 10.1016/s0065-2776(01)77014-9. Adv Immunol. 2001. PMID: 11293120 Review. No abstract available.
Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attack.
van der Goot FG, Harder T. van der Goot FG, et al. Among authors: harder t. Semin Immunol. 2001 Apr;13(2):89-97. doi: 10.1006/smim.2000.0300. Semin Immunol. 2001. PMID: 11308292 Review.
Induction of caveolae in the apical plasma membrane of Madin-Darby canine kidney cells.
Verkade P, Harder T, Lafont F, Simons K. Verkade P, et al. Among authors: harder t. J Cell Biol. 2000 Feb 21;148(4):727-39. doi: 10.1083/jcb.148.4.727. J Cell Biol. 2000. PMID: 10684254 Free PMC article.
Whereas antibody cross-linking induced the formation of large clusters on the basolateral membrane, resembling those observed on the surface of fibroblasts (Harder, T., P. ...
Whereas antibody cross-linking induced the formation of large clusters on the basolateral membrane, resembling those observed on the surface …
Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies.
Harder T, Kuhn M. Harder T, et al. J Cell Biol. 2000 Oct 16;151(2):199-208. doi: 10.1083/jcb.151.2.199. J Cell Biol. 2000. PMID: 11038169 Free PMC article.
Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexes. ...Here, we studied the assembly of TCR with signal transduction proteins and raft markers in plasma membrane subdomains of Jurkat T
Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexe …
Lipid domain structure of the plasma membrane revealed by patching of membrane components.
Harder T, Scheiffele P, Verkade P, Simons K. Harder T, et al. J Cell Biol. 1998 May 18;141(4):929-42. doi: 10.1083/jcb.141.4.929. J Cell Biol. 1998. PMID: 9585412 Free PMC article.
The patches of these raft markers overlapped extensively in BHK cells as well as in Jurkat T-lymphoma cells. Importantly, patches of GPI-anchored PLAP accumulated src-like protein tyrosine kinase fyn, which is thought to be anchored in the cytoplasmic leaflet of raft domai …
The patches of these raft markers overlapped extensively in BHK cells as well as in Jurkat T-lymphoma cells. Importantly, patches of …
Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains.
Harder T, Simons K. Harder T, et al. Curr Opin Cell Biol. 1997 Aug;9(4):534-42. doi: 10.1016/s0955-0674(97)80030-0. Curr Opin Cell Biol. 1997. PMID: 9261060 Review.
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