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Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities.
Carling D, Clarke PR, Zammit VA, Hardie DG. Carling D, et al. Among authors: hardie dg. Eur J Biochem. 1989 Dec 8;186(1-2):129-36. doi: 10.1111/j.1432-1033.1989.tb15186.x. Eur J Biochem. 1989. PMID: 2598924
Evidence that glucagon-mediated inhibition of acetyl-CoA carboxylase in isolated adipocytes involves increased phosphorylation of the enzyme by cyclic AMP-dependent protein kinase.
Holland R, Hardie DG, Clegg RA, Zammit VA. Holland R, et al. Among authors: hardie dg. Biochem J. 1985 Feb 15;226(1):139-45. doi: 10.1042/bj2260139. Biochem J. 1985. PMID: 2858203 Free PMC article.
Glucagon treatment of adipocytes led to increased phosphorylation of acetyl-CoA carboxylase in the same chymotryptic peptide as that containing the major site phosphorylated on the enzyme by purified cyclic AMP-dependent protein kinase in vitro [Munday & Hardie (1984) …
Glucagon treatment of adipocytes led to increased phosphorylation of acetyl-CoA carboxylase in the same chymotryptic peptide as that contain …
Histological evaluation of AMPK signalling in primary breast cancer.
Hadad SM, Baker L, Quinlan PR, Robertson KE, Bray SE, Thomson G, Kellock D, Jordan LB, Purdie CA, Hardie DG, Fleming S, Thompson AM. Hadad SM, et al. Among authors: hardie dg. BMC Cancer. 2009 Sep 1;9:307. doi: 10.1186/1471-2407-9-307. BMC Cancer. 2009. PMID: 19723334 Free PMC article.
Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection.
Hardie DG. Hardie DG. Cold Spring Harb Symp Quant Biol. 2011;76:155-64. doi: 10.1101/sqb.2011.76.010819. Epub 2011 Nov 9. Cold Spring Harb Symp Quant Biol. 2011. PMID: 22071265 Review.
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.
Fogarty S, Hardie DG. Fogarty S, et al. Among authors: hardie dg. Biochim Biophys Acta. 2010 Mar;1804(3):581-91. doi: 10.1016/j.bbapap.2009.09.012. Epub 2009 Sep 22. Biochim Biophys Acta. 2010. PMID: 19778642 Review.
Metabolic control: a new solution to an old problem.
Hardie DG. Hardie DG. Curr Biol. 2000 Oct 19;10(20):R757-9. doi: 10.1016/s0960-9822(00)00744-2. Curr Biol. 2000. PMID: 11069102 Review.
Cloning of DNA encoding a catalytic subunit of SNF1-related protein kinase-1 (SnRK1-alpha1), and immunological analysis of multiple forms of the kinase, in spinach leaf.
Crawford RM, Halford NG, Hardie DG. Crawford RM, et al. Among authors: hardie dg. Plant Mol Biol. 2001 Apr;45(6):731-41. doi: 10.1023/a:1010600603276. Plant Mol Biol. 2001. PMID: 11430435
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
Lochhead PA, Salt IP, Walker KS, Hardie DG, Sutherland C. Lochhead PA, et al. Among authors: hardie dg. Diabetes. 2000 Jun;49(6):896-903. doi: 10.2337/diabetes.49.6.896. Diabetes. 2000. PMID: 10866040
Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5'-AMP.
Sugden C, Crawford RM, Halford NG, Hardie DG. Sugden C, et al. Among authors: hardie dg. Plant J. 1999 Aug;19(4):433-9. doi: 10.1046/j.1365-313x.1999.00532.x. Plant J. 1999. PMID: 10504565
Analysis of the role of the AMP-activated protein kinase in the response to cellular stress.
Hardie DG, Salt IP, Davies SP. Hardie DG, et al. Methods Mol Biol. 2000;99:63-74. doi: 10.1385/1-59259-054-3:63. Methods Mol Biol. 2000. PMID: 10909077 Review. No abstract available.
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