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5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.
Davies SP, Helps NR, Cohen PT, Hardie DG. Davies SP, et al. Among authors: hardie dg. FEBS Lett. 1995 Dec 27;377(3):421-5. doi: 10.1016/0014-5793(95)01368-7. FEBS Lett. 1995. PMID: 8549768
Histological evaluation of AMPK signalling in primary breast cancer.
Hadad SM, Baker L, Quinlan PR, Robertson KE, Bray SE, Thomson G, Kellock D, Jordan LB, Purdie CA, Hardie DG, Fleming S, Thompson AM. Hadad SM, et al. Among authors: hardie dg. BMC Cancer. 2009 Sep 1;9:307. doi: 10.1186/1471-2407-9-307. BMC Cancer. 2009. PMID: 19723334 Free PMC article.
Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection.
Hardie DG. Hardie DG. Cold Spring Harb Symp Quant Biol. 2011;76:155-64. doi: 10.1101/sqb.2011.76.010819. Epub 2011 Nov 9. Cold Spring Harb Symp Quant Biol. 2011. PMID: 22071265 Review.
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.
Fogarty S, Hardie DG. Fogarty S, et al. Among authors: hardie dg. Biochim Biophys Acta. 2010 Mar;1804(3):581-91. doi: 10.1016/j.bbapap.2009.09.012. Epub 2009 Sep 22. Biochim Biophys Acta. 2010. PMID: 19778642 Review.
Metabolic control: a new solution to an old problem.
Hardie DG. Hardie DG. Curr Biol. 2000 Oct 19;10(20):R757-9. doi: 10.1016/s0960-9822(00)00744-2. Curr Biol. 2000. PMID: 11069102 Review.
Cloning of DNA encoding a catalytic subunit of SNF1-related protein kinase-1 (SnRK1-alpha1), and immunological analysis of multiple forms of the kinase, in spinach leaf.
Crawford RM, Halford NG, Hardie DG. Crawford RM, et al. Among authors: hardie dg. Plant Mol Biol. 2001 Apr;45(6):731-41. doi: 10.1023/a:1010600603276. Plant Mol Biol. 2001. PMID: 11430435
Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.
Fryer LG, Hajduch E, Rencurel F, Salt IP, Hundal HS, Hardie DG, Carling D. Fryer LG, et al. Among authors: hardie dg. Diabetes. 2000 Dec;49(12):1978-85. doi: 10.2337/diabetes.49.12.1978. Diabetes. 2000. PMID: 11117997
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
Lochhead PA, Salt IP, Walker KS, Hardie DG, Sutherland C. Lochhead PA, et al. Among authors: hardie dg. Diabetes. 2000 Jun;49(6):896-903. doi: 10.2337/diabetes.49.6.896. Diabetes. 2000. PMID: 10866040
The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1.
Smith FC, Davies SP, Wilson WA, Carling D, Hardie DG. Smith FC, et al. Among authors: hardie dg. FEBS Lett. 1999 Jun 18;453(1-2):219-23. doi: 10.1016/s0014-5793(99)00725-5. FEBS Lett. 1999. PMID: 10403407
Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5'-AMP.
Sugden C, Crawford RM, Halford NG, Hardie DG. Sugden C, et al. Among authors: hardie dg. Plant J. 1999 Aug;19(4):433-9. doi: 10.1046/j.1365-313x.1999.00532.x. Plant J. 1999. PMID: 10504565
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