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Year Number of Results
2003 3
2004 1
2006 3
2007 3
2008 1
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2010 5
2011 1
2012 1
2013 1
2014 1
2015 2
2018 1
2020 1
2022 0
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TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Drage MG, Pecora ND, Hise AG, Febbraio M, Silverstein RL, Golenbock DT, Boom WH, Harding CV. Drage MG, et al. Among authors: harding cv. Cell Immunol. 2009;258(1):29-37. doi: 10.1016/j.cellimm.2009.03.008. Epub 2009 Apr 11. Cell Immunol. 2009. PMID: 19362712 Free PMC article.
Mycobacterium tuberculosis (Mtb) signals through Toll-like receptor 2 (TLR2) to regulate antigen presenting cells (APCs). Mtb lipoproteins, including LpqH, LprA, LprG and PhoS1, are TLR2 agonists, but their co-receptor requirements are unknown. We studied Mtb lipopr …
Mycobacterium tuberculosis (Mtb) signals through Toll-like receptor 2 (TLR2) to regulate antigen presenting cells (APCs). Mtb lipopro …
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
Reba SM, Li Q, Onwuzulike S, Ding X, Karim AF, Hernandez Y, Fulton SA, Harding CV, Lancioni CL, Nagy N, Rodriguez ME, Wearsch PA, Rojas RE. Reba SM, et al. Among authors: harding cv. Eur J Immunol. 2014 May;44(5):1410-21. doi: 10.1002/eji.201344100. Epub 2014 Mar 14. Eur J Immunol. 2014. PMID: 24497180 Free PMC article.
Like their human counterparts, mouse CD4(+) T cells express TLR2 and respond to TLR2 costimulation in vitro. This Th1-like response was observed in the context of both polyclonal and Ag-specific TCR stimulation. To evaluate the role of T-cell TLR2 in priming …
Like their human counterparts, mouse CD4(+) T cells express TLR2 and respond to TLR2 costimulation in vitro. This Th1-like res …
TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9.
Liu YC, Simmons DP, Li X, Abbott DW, Boom WH, Harding CV. Liu YC, et al. Among authors: harding cv. J Immunol. 2012 Feb 1;188(3):1019-26. doi: 10.4049/jimmunol.1102181. Epub 2012 Jan 6. J Immunol. 2012. PMID: 22227568 Free PMC article.
Pathogens may signal through multiple TLRs with synergistic or antagonistic effects on the induction of cytokines, including type I IFN (IFN-I). IFN-I is typically induced by TLR9, but not TLR2. Moreover, we previously reported that TLR2 signaling by Mycobacterium t …
Pathogens may signal through multiple TLRs with synergistic or antagonistic effects on the induction of cytokines, including type I IFN (IFN …
Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9.
Simmons DP, Canaday DH, Liu Y, Li Q, Huang A, Boom WH, Harding CV. Simmons DP, et al. Among authors: harding cv. J Immunol. 2010 Aug 15;185(4):2405-15. doi: 10.4049/jimmunol.0904005. Epub 2010 Jul 21. J Immunol. 2010. PMID: 20660347 Free PMC article.
Unmethylated CpG DNA signals through TLR9 to induce type I IFN (IFN-alpha/beta), which enhances MHC-I Ag cross processing, but lipoproteins that signal through TLR2 do not induce IFN-alpha/beta. In these studies we observed that M. tuberculosis, which expresses agonists of …
Unmethylated CpG DNA signals through TLR9 to induce type I IFN (IFN-alpha/beta), which enhances MHC-I Ag cross processing, but lipoproteins …
Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors.
Harding CV, Boom WH. Harding CV, et al. Nat Rev Microbiol. 2010 Apr;8(4):296-307. doi: 10.1038/nrmicro2321. Nat Rev Microbiol. 2010. PMID: 20234378 Free PMC article. Review.
Immune evasion allows M. tuberculosis to establish persistent or latent infection in macrophages and results in Toll-like receptor 2 (TLR2)-dependent inhibition of MHC class II transactivator expression, MHC class II molecule expression and antigen presentation. ...
Immune evasion allows M. tuberculosis to establish persistent or latent infection in macrophages and results in Toll-like receptor 2 (TLR
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
Jo EK, Yang CS, Choi CH, Harding CV. Jo EK, et al. Among authors: harding cv. Cell Microbiol. 2007 May;9(5):1087-98. doi: 10.1111/j.1462-5822.2007.00914.x. Epub 2007 Mar 13. Cell Microbiol. 2007. PMID: 17359235 Review.
Recent studies have revealed the intracellular signalling cascades involved in the TLR-initiated immune response to mycobacterial infection. Although both TLR2 and TLR4 have been implicated in host interactions with Mtb, the relationship between specific mycobacterial mole …
Recent studies have revealed the intracellular signalling cascades involved in the TLR-initiated immune response to mycobacterial infection. …
Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.
Pecora ND, Gehring AJ, Canaday DH, Boom WH, Harding CV. Pecora ND, et al. Among authors: harding cv. J Immunol. 2006 Jul 1;177(1):422-9. doi: 10.4049/jimmunol.177.1.422. J Immunol. 2006. PMID: 16785538 Free article.
TLR2 recognizes components of Mycobacterium tuberculosis (Mtb) and initiates responses by APCs that influence both innate and adaptive immunity. Mtb lipoproteins are an important class of TLR2 ligand, but only two, LpqH and LprG, have been characterized to date. ...
TLR2 recognizes components of Mycobacterium tuberculosis (Mtb) and initiates responses by APCs that influence both innate and adaptiv
Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling.
Shin DM, Yuk JM, Lee HM, Lee SH, Son JW, Harding CV, Kim JM, Modlin RL, Jo EK. Shin DM, et al. Among authors: harding cv. Cell Microbiol. 2010 Nov;12(11):1648-65. doi: 10.1111/j.1462-5822.2010.01497.x. Epub 2010 Jul 20. Cell Microbiol. 2010. PMID: 20560977 Free PMC article.
Here we show that TLR2/1/CD14 stimulation by mycobacterial lipoprotein LpqH can robustly activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. ...Furthermore, these results establish a previously uncharacterized signa …
Here we show that TLR2/1/CD14 stimulation by mycobacterial lipoprotein LpqH can robustly activate antibacterial autophagy through vit …
Mycobacterium tuberculosis Lipoprotein and Lipoglycan Binding to Toll-Like Receptor 2 Correlates with Agonist Activity and Functional Outcomes.
Shukla S, Richardson ET, Drage MG, Boom WH, Harding CV. Shukla S, et al. Among authors: harding cv. Infect Immun. 2018 Sep 21;86(10):e00450-18. doi: 10.1128/IAI.00450-18. Print 2018 Oct. Infect Immun. 2018. PMID: 30037791 Free PMC article.
Here, we directly measured M. tuberculosis lipoprotein and lipoglycan binding to TLR2 and its partner receptor, TLR1. LprG, LAM, and LM were all found to bind to TLR2 in the absence of TLR1, but not to TLR1 in the absence of TLR2. Trimolecular interactions we …
Here, we directly measured M. tuberculosis lipoprotein and lipoglycan binding to TLR2 and its partner receptor, TLR1. LprG, LAM, and …
Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages.
Groft SG, Nagy N, Boom WH, Harding CV. Groft SG, et al. Among authors: harding cv. Infect Immun. 2020 Dec 15;89(1):e00323-20. doi: 10.1128/IAI.00323-20. Print 2020 Dec 15. Infect Immun. 2020. PMID: 33077627 Free PMC article.
This study investigated responses to Toll-like receptor 2 (TLR2)-driven extracellular signal-related kinase (ERK) signaling in dendritic cells (DCs) versus macrophages. TLR2 signaling was induced with Pam(3)Cys-Ser-Lys(4), and the role of ERK signaling was interroga …
This study investigated responses to Toll-like receptor 2 (TLR2)-driven extracellular signal-related kinase (ERK) signaling in dendri …
25 results