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114 results
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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase.
Harding HP, Zhang Y, Ron D. Harding HP, et al. Nature. 1999 Jan 21;397(6716):271-4. doi: 10.1038/16729. Nature. 1999. PMID: 9930704
Cloning of mammalian Ire1 reveals diversity in the ER stress responses.
Wang XZ, Harding HP, Zhang Y, Jolicoeur EM, Kuroda M, Ron D. Wang XZ, et al. Among authors: harding hp. EMBO J. 1998 Oct 1;17(19):5708-17. doi: 10.1093/emboj/17.19.5708. EMBO J. 1998. PMID: 9755171 Free PMC article.
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. Urano F, et al. Among authors: harding hp. Science. 2000 Jan 28;287(5453):664-6. doi: 10.1126/science.287.5453.664. Science. 2000. PMID: 10650002
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response.
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Bertolotti A, et al. Among authors: harding hp. Nat Cell Biol. 2000 Jun;2(6):326-32. doi: 10.1038/35014014. Nat Cell Biol. 2000. PMID: 10854322
Perk is essential for translational regulation and cell survival during the unfolded protein response.
Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. Harding HP, et al. Mol Cell. 2000 May;5(5):897-904. doi: 10.1016/s1097-2765(00)80330-5. Mol Cell. 2000. PMID: 10882126
Regulated translation initiation controls stress-induced gene expression in mammalian cells.
Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. Harding HP, et al. Mol Cell. 2000 Nov;6(5):1099-108. doi: 10.1016/s1097-2765(00)00108-8. Mol Cell. 2000. PMID: 11106749
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha.
Novoa I, Zeng H, Harding HP, Ron D. Novoa I, et al. Among authors: harding hp. J Cell Biol. 2001 May 28;153(5):1011-22. doi: 10.1083/jcb.153.5.1011. J Cell Biol. 2001. PMID: 11381086 Free PMC article.
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival.
Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D. Harding HP, et al. Mol Cell. 2001 Jun;7(6):1153-63. doi: 10.1016/s1097-2765(01)00264-7. Mol Cell. 2001. PMID: 11430819
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D. Calfon M, et al. Among authors: harding hp. Nature. 2002 Jan 3;415(6867):92-6. doi: 10.1038/415092a. Nature. 2002. PMID: 11780124
Transcriptional and translational control in the Mammalian unfolded protein response.
Harding HP, Calfon M, Urano F, Novoa I, Ron D. Harding HP, et al. Annu Rev Cell Dev Biol. 2002;18:575-99. doi: 10.1146/annurev.cellbio.18.011402.160624. Epub 2002 Apr 2. Annu Rev Cell Dev Biol. 2002. PMID: 12142265 Review.
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