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Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C. Rojo R, et al. Among authors: hardingham ge. Nat Commun. 2019 Jul 19;10(1):3215. doi: 10.1038/s41467-019-11053-8. Nat Commun. 2019. PMID: 31324781 Free PMC article.
SynGAP isoforms exert opposing effects on synaptic strength.
McMahon AC, Barnett MW, O'Leary TS, Stoney PN, Collins MO, Papadia S, Choudhary JS, Komiyama NH, Grant SG, Hardingham GE, Wyllie DJ, Kind PC. McMahon AC, et al. Among authors: hardingham ge. Nat Commun. 2012 Jun 12;3:900. doi: 10.1038/ncomms1900. Nat Commun. 2012. PMID: 22692543 Free PMC article.
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, Scannevin RH, Chandran S, Hayes JD, Hardingham GE. Bell KF, et al. Among authors: hardingham ge. Nat Commun. 2015 May 13;6:7066. doi: 10.1038/ncomms8066. Nat Commun. 2015. PMID: 25967870 Free PMC article.
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.
Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, Galea E, Chandran S, Wyllie DJA, Simpson TI, Hardingham GE. Hasel P, et al. Among authors: hardingham ge. Nat Commun. 2017 May 2;8:15132. doi: 10.1038/ncomms15132. Nat Commun. 2017. PMID: 28462931 Free PMC article.
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.
Jiwaji Z, Tiwari SS, Avilés-Reyes RX, Hooley M, Hampton D, Torvell M, Johnson DA, McQueen J, Baxter P, Sabari-Sankar K, Qiu J, He X, Fowler J, Febery J, Gregory J, Rose J, Tulloch J, Loan J, Story D, McDade K, Smith AM, Greer P, Ball M, Kind PC, Matthews PM, Smith C, Dando O, Spires-Jones TL, Johnson JA, Chandran S, Hardingham GE. Jiwaji Z, et al. Among authors: hardingham ge. Nat Commun. 2022 Jan 10;13(1):135. doi: 10.1038/s41467-021-27702-w. Nat Commun. 2022. PMID: 35013236 Free PMC article.
Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.
Molina-Gonzalez I, Holloway RK, Jiwaji Z, Dando O, Kent SA, Emelianova K, Lloyd AF, Forbes LH, Mahmood A, Skripuletz T, Gudi V, Febery JA, Johnson JA, Fowler JH, Kuhlmann T, Williams A, Chandran S, Stangel M, Howden AJM, Hardingham GE, Miron VE. Molina-Gonzalez I, et al. Among authors: hardingham ge. Nat Commun. 2023 Jun 8;14(1):3372. doi: 10.1038/s41467-023-39046-8. Nat Commun. 2023. PMID: 37291151 Free PMC article.
143 results