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The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.
Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW. Shembade N, et al. Among authors: harhaj ns. EMBO J. 2009 Mar 4;28(5):513-22. doi: 10.1038/emboj.2008.285. Epub 2009 Jan 8. EMBO J. 2009. PMID: 19131965 Free PMC article.
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Shembade N, Pujari R, Harhaj NS, Abbott DW, Harhaj EW. Shembade N, et al. Among authors: harhaj ns. Nat Immunol. 2011 Jul 17;12(9):834-43. doi: 10.1038/ni.2066. Nat Immunol. 2011. PMID: 21765415 Free PMC article.
Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1.
Charoenthongtrakul S, Zhou Q, Shembade N, Harhaj NS, Harhaj EW. Charoenthongtrakul S, et al. Among authors: harhaj ns. J Virol. 2011 Jul;85(14):6955-62. doi: 10.1128/JVI.00007-11. Epub 2011 May 18. J Virol. 2011. PMID: 21593151 Free PMC article.
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20.
Shembade N, Harhaj NS, Parvatiyar K, Copeland NG, Jenkins NA, Matesic LE, Harhaj EW. Shembade N, et al. Among authors: harhaj ns. Nat Immunol. 2008 Mar;9(3):254-62. doi: 10.1038/ni1563. Epub 2008 Feb 3. Nat Immunol. 2008. PMID: 18246070
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW. Shembade N, et al. Among authors: harhaj ns. J Virol. 2007 Dec;81(24):13735-42. doi: 10.1128/JVI.01790-07. Epub 2007 Oct 17. J Virol. 2007. PMID: 17942533 Free PMC article.
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
Shembade N, Harhaj NS, Liebl DJ, Harhaj EW. Shembade N, et al. Among authors: harhaj ns. EMBO J. 2007 Sep 5;26(17):3910-22. doi: 10.1038/sj.emboj.7601823. Epub 2007 Aug 16. EMBO J. 2007. PMID: 17703191 Free PMC article.
Deregulated expression of CD40 ligand in HTLV-I infection: distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients.
Harhaj NS, Janic B, Ramos JC, Harrington WJ Jr, Harhaj EW. Harhaj NS, et al. Virology. 2007 May 25;362(1):99-108. doi: 10.1016/j.virol.2006.12.020. Epub 2007 Jan 26. Virology. 2007. PMID: 17258259 Free PMC article.
Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase.
Harhaj NS, Sun SC, Harhaj EW. Harhaj NS, et al. J Biol Chem. 2007 Feb 9;282(6):4185-92. doi: 10.1074/jbc.M611031200. Epub 2006 Dec 4. J Biol Chem. 2007. PMID: 17145747 Free article.
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
Harhaj EW, Harhaj NS. Harhaj EW, et al. Among authors: harhaj ns. IUBMB Life. 2005 Feb;57(2):83-91. doi: 10.1080/15216540500078715. IUBMB Life. 2005. PMID: 16036567 Free article. Review.
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