Harker A - Search Results

1

Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids.

Taylor S, Harker A. Taylor S, et al. Among authors: harker a. J Pharm Biomed Anal. 2006 Apr 11;41(1):299-303. doi: 10.1016/j.jpba.2005.10.031. Epub 2005 Nov 28. J Pharm Biomed Anal. 2006. PMID: 16314065

2

Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator.

Ward SE, Harries M, Aldegheri L, Andreotti D, Ballantine S, Bax BD, Harris AJ, Harker AJ, Lund J, Melarange R, Mingardi A, Mookherjee C, Mosley J, Neve M, Oliosi B, Profeta R, Smith KJ, Smith PW, Spada S, Thewlis KM, Yusaf SP. Ward SE, et al. Among authors: harker aj. J Med Chem. 2010 Aug 12;53(15):5801-12. doi: 10.1021/jm1005429. J Med Chem. 2010. PMID: 20614889 Clinical Trial.

3

Oxazolidinones as novel human CCR8 antagonists.

Jin J, Wang Y, Wang F, Kerns JK, Vinader VM, Hancock AP, Lindon MJ, Stevenson GI, Morrow DM, Rao P, Nguyen C, Barrett VJ, Browning C, Hartmann G, Andrew DP, Sarau HM, Foley JJ, Jurewicz AJ, Fornwald JA, Harker AJ, Moore ML, Rivero RA, Belmonte KE, Connor HE. Jin J, et al. Among authors: harker aj. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1722-5. doi: 10.1016/j.bmcl.2006.12.076. Epub 2006 Dec 24. Bioorg Med Chem Lett. 2007. PMID: 17267215

4

Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism.

Biggadike K, Angell RM, Burgess CM, Farrell RM, Hancock AP, Harker AJ, Irving WR, Ioannou C, Procopiou PA, Shaw RE, Solanke YE, Singh OM, Snowden MA, Stubbs RJ, Walton S, Weston HE. Biggadike K, et al. Among authors: harker aj. J Med Chem. 2000 Jan 13;43(1):19-21. doi: 10.1021/jm990436t. J Med Chem. 2000. PMID: 10633034 No abstract available.

5

Automated high-performance liquid chromatographic method for the determination of a neuraminidase inhibitor (GG167) in human serum by pre-column fluorescence derivatisation using benzoin.

Stubbs RJ, Harker AJ. Stubbs RJ, et al. Among authors: harker aj. J Chromatogr B Biomed Appl. 1995 Aug 18;670(2):279-85. doi: 10.1016/0378-4347(95)00165-4. J Chromatogr B Biomed Appl. 1995. PMID: 8548018

6

High-performance chromatographic assay for the sulphoxide metabolite of 2'-deoxy-3'-thiacytidine in human urine.

Plumb RS, Gray RD, Harker AJ, Taylor S. Plumb RS, et al. Among authors: harker aj. J Chromatogr B Biomed Appl. 1996 Dec 13;687(2):457-61. doi: 10.1016/s0378-4347(96)00247-2. J Chromatogr B Biomed Appl. 1996. PMID: 9017472

7

Combining high-throughput pharmacokinetic screens at the hits-to-leads stage of drug discovery.

Spalding DJ, Harker AJ, Bayliss MK. Spalding DJ, et al. Among authors: harker aj. Drug Discov Today. 2000 Dec 1;5(12 Suppl 1):70-76. doi: 10.1016/s1359-6446(00)00061-1. Drug Discov Today. 2000. PMID: 11564569

8

Absorption, distribution and excretion of lacidipine, a dihydropyridine calcium antagonist, in rat and dog.

Pellegatti M, Grossi P, Ayrton J, Evans GL, Harker AJ. Pellegatti M, et al. Among authors: harker aj. Xenobiotica. 1990 Aug;20(8):765-77. doi: 10.3109/00498259009046891. Xenobiotica. 1990. PMID: 2219960

9

High-performance liquid chromatographic assay for 2'-deoxy-3'-thiacytidine in human serum.

Harker AJ, Evans GL, Hawley AE, Morris DM. Harker AJ, et al. J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):227-32. doi: 10.1016/0378-4347(94)80092-8. J Chromatogr B Biomed Appl. 1994. PMID: 7952073

10

Interspecies scaling and pharmacokinetic parameters of 3TC in humans.

Hussey EK, Donn KH, Daniel MJ, Hall ST, Harker AJ, Evans GL. Hussey EK, et al. Among authors: harker aj. J Clin Pharmacol. 1994 Oct;34(10):975-7. doi: 10.1002/j.1552-4604.1994.tb01968.x. J Clin Pharmacol. 1994. PMID: 7530728 Clinical Trial.

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