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CRISPR-Cas12a: Functional overview and applications.
Paul B, Montoya G. Paul B, et al. Biomed J. 2020 Feb;43(1):8-17. doi: 10.1016/j.bj.2019.10.005. Epub 2020 Feb 5. Biomed J. 2020. PMID: 32200959 Free PMC article. Review.
Prokaryotes have developed an adaptive immune system called Clustered regularly interspaced short palindromic repeats (CRISPR) to combat attacks by foreign mobile genetic elements (MGEs) such as plasmids and phages. In the past decade, the widely characterized CR
Prokaryotes have developed an adaptive immune system called Clustered regularly interspaced short palindromic repeats (CRISPR) to com …
Genome engineering using CRISPR-Cas9 system.
Cong L, Zhang F. Cong L, et al. Methods Mol Biol. 2015;1239:197-217. doi: 10.1007/978-1-4939-1862-1_10. Methods Mol Biol. 2015. PMID: 25408407
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 system is an adaptive immune system that exists in a variety of microbes. It could be engineered to function in eukaryotic cells as a fast, low-cost, efficient, and scalable tool for …
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 system is an adaptive immune system that ex …
Harnessing CRISPR-Cas9 immunity for genetic engineering.
Charpentier E, Marraffini LA. Charpentier E, et al. Curr Opin Microbiol. 2014 Jun;19:114-119. doi: 10.1016/j.mib.2014.07.001. Epub 2014 Jul 19. Curr Opin Microbiol. 2014. PMID: 25048165 Free PMC article.
CRISPR-Cas encodes an adaptive immune system that defends prokaryotes against infectious viruses and plasmids. ...Using synthetic single RNA guides, Cas9 can be reprogrammed to create specific double-stranded DNA breaks in the genomes of a variety of organisms, ranging fro …
CRISPR-Cas encodes an adaptive immune system that defends prokaryotes against infectious viruses and plasmids. ...Using synthetic sin …
Harnessing CRISPR-Cas9 for Genome Editing in Streptococcus pneumoniae D39V.
Synefiaridou D, Veening JW. Synefiaridou D, et al. Appl Environ Microbiol. 2021 Feb 26;87(6):e02762-20. doi: 10.1128/AEM.02762-20. Print 2021 Feb 26. Appl Environ Microbiol. 2021. PMID: 33397704 Free PMC article.
CRISPR-Cas systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by the detection and cleavage of invading foreign DNA. ...Here, we introduced an easy-to-use system to perform multiple rounds of genome editing in the pneumococcus by putti …
CRISPR-Cas systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by the detection and cleavage of …
A human apolipoprotein L with detergent-like activity kills intracellular pathogens.
Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, Xu D, Mamiñska A, Nguyen TN, Lazarou M, Karatekin E, Gupta K, MacMicking JD. Gaudet RG, et al. Science. 2021 Jul 16;373(6552):eabf8113. doi: 10.1126/science.abf8113. Science. 2021. PMID: 34437126 Free PMC article.
Activation of cell-autonomous defense by the immune cytokine interferon-gamma (IFN-gamma) is critical to the control of life-threatening infections in humans. IFN-gamma induces the expression of hundreds of host proteins in all nucleated cells and tissues, yet many of thes …
Activation of cell-autonomous defense by the immune cytokine interferon-gamma (IFN-gamma) is critical to the control of life-threaten …
Engineering disease resistant plants through CRISPR-Cas9 technology.
Tyagi S, Kumar R, Kumar V, Won SY, Shukla P. Tyagi S, et al. GM Crops Food. 2021 Jan 2;12(1):125-144. doi: 10.1080/21645698.2020.1831729. GM Crops Food. 2021. PMID: 33079628 Free PMC article. Review.
In this context, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) has transformed genome editing (GE) technology and being harnessed for altering the traits. Here we have summarized the complexities of plant immune
In this context, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) has transformed genom …
Engineering Plants for Geminivirus Resistance with CRISPR/Cas9 System.
Zaidi SS, Mansoor S, Ali Z, Tashkandi M, Mahfouz MM. Zaidi SS, et al. Trends Plant Sci. 2016 Apr;21(4):279-281. doi: 10.1016/j.tplants.2016.01.023. Epub 2016 Feb 12. Trends Plant Sci. 2016. PMID: 26880316
The CRISPR/Cas9 system is an efficient genome-editing platform for diverse eukaryotic species, including plants. Recent work harnessed CRISPR/Cas9 technology to engineer resistance to geminiviruses. ...
The CRISPR/Cas9 system is an efficient genome-editing platform for diverse eukaryotic species, including plants. Recent work …
Harnessing CRISPR/Cas9 for Enhanced Disease Resistance in Hot Peppers: A Comparative Study on CaMLO2-Gene-Editing Efficiency across Six Cultivars.
Park JH, Kim H. Park JH, et al. Int J Mol Sci. 2023 Nov 26;24(23):16775. doi: 10.3390/ijms242316775. Int J Mol Sci. 2023. PMID: 38069102 Free PMC article.
Recent advancements in genome editing, particularly using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9, have unlocked unprecedented opportunities for modifying disease-resistant genes and improving crop characteristics. ...This study addre …
Recent advancements in genome editing, particularly using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9
Unraveling the potential of CRISPR-Cas9 for gene therapy.
Barrangou R, May AP. Barrangou R, et al. Expert Opin Biol Ther. 2015 Mar;15(3):311-4. doi: 10.1517/14712598.2015.994501. Epub 2014 Dec 23. Expert Opin Biol Ther. 2015. PMID: 25535790
The molecular machinery from the prokaryotic clustered regularly interspaced short palindromic repeats (CRISPR)-Cas immune system has broadly been repurposed for genome editing in eukaryotes. In particular, the sequence-specific Cas9 endonuclease can be flexibly harness
The molecular machinery from the prokaryotic clustered regularly interspaced short palindromic repeats (CRISPR)-Cas immune system has …
Antiviral Goes Viral: Harnessing CRISPR/Cas9 to Combat Viruses in Humans.
Soppe JA, Lebbink RJ. Soppe JA, et al. Trends Microbiol. 2017 Oct;25(10):833-850. doi: 10.1016/j.tim.2017.04.005. Epub 2017 May 15. Trends Microbiol. 2017. PMID: 28522157 Review.
A rewired CRISPR/Cas9 system can be used for targeted and precise genome editing in eukaryotic cells. ...Here, we review recent CRISPR/Cas9-based approaches to combat specific human viruses in humans and discuss challenges that need to be overcome befo …
A rewired CRISPR/Cas9 system can be used for targeted and precise genome editing in eukaryotic cells. ...Here, we review recen …
31 results