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CRISPR-Cas12a: Functional overview and applications.
Paul B, Montoya G. Paul B, et al. Biomed J. 2020 Feb;43(1):8-17. doi: 10.1016/j.bj.2019.10.005. Epub 2020 Feb 5. Biomed J. 2020. PMID: 32200959 Free PMC article. Review.
Prokaryotes have developed an adaptive immune system called Clustered regularly interspaced short palindromic repeats (CRISPR) to combat attacks by foreign mobile genetic elements (MGEs) such as plasmids and phages. In the past decade, the widely characterized CR …
Prokaryotes have developed an adaptive immune system called Clustered regularly interspaced short palindromic repeats (CRISPR) to com …
Genome engineering using CRISPR-Cas9 system.
Cong L, Zhang F. Cong L, et al. Methods Mol Biol. 2015;1239:197-217. doi: 10.1007/978-1-4939-1862-1_10. Methods Mol Biol. 2015. PMID: 25408407
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 system is an adaptive immune system that exists in a variety of microbes. ...In this chapter, detailed protocols are described for harnessing the CRISPR-Cas9 syst …
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 system is an adaptive immune system that ex …
Harnessing CRISPR-Cas9 immunity for genetic engineering.
Charpentier E, Marraffini LA. Charpentier E, et al. Curr Opin Microbiol. 2014 Jun;19:114-119. doi: 10.1016/j.mib.2014.07.001. Epub 2014 Jul 19. Curr Opin Microbiol. 2014. PMID: 25048165 Free PMC article.
CRISPR-Cas encodes an adaptive immune system that defends prokaryotes against infectious viruses and plasmids. Immunity is mediated by Cas nucleases, which use small RNA guides (the crRNAs) to specify a cleavage site within the genome of invading nucleic acids. ...U …
CRISPR-Cas encodes an adaptive immune system that defends prokaryotes against infectious viruses and plasmids. Immunity is med …
Harnessing the evolving CRISPR/Cas9 for precision oncology.
Li T, Li S, Kang Y, Zhou J, Yi M. Li T, et al. J Transl Med. 2024 Aug 8;22(1):749. doi: 10.1186/s12967-024-05570-4. J Transl Med. 2024. PMID: 39118151 Free PMC article. Review.
The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas9 system, a groundbreaking innovation in genetic engineering, has revolutionized our approach to surmounting complex diseases, culminating in CASGEVY approved for sickle cell ane …
The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas9 system, a groundbreaking innovation in genetic …
Harnessing CRISPR/Cas9 in engineering biotic stress immunity in crops.
Yerlikaya BA, Yerlikaya S, Gül B, Yoldaş H, Kavas M, Mohamed HI. Yerlikaya BA, et al. Planta. 2025 Jul 15;262(3):54. doi: 10.1007/s00425-025-04769-z. Planta. 2025. PMID: 40663257 Review.
There is significant potential for CRISPR/Cas9 to be used in developing crops that can adapt to biotic stresses such as fungal, bacterial, viral, and pest infections and weeds. ...Potential applications of CRISPR/Cas9 in crop protection involve introdu …
There is significant potential for CRISPR/Cas9 to be used in developing crops that can adapt to biotic stresses such as fungal …
Harnessing CRISPR-Cas9 for Genome Editing in Streptococcus pneumoniae D39V.
Synefiaridou D, Veening JW. Synefiaridou D, et al. Appl Environ Microbiol. 2021 Feb 26;87(6):e02762-20. doi: 10.1128/AEM.02762-20. Print 2021 Feb 26. Appl Environ Microbiol. 2021. PMID: 33397704 Free PMC article.
Here, we developed a replicative plasmid that carries the CRISPR-Cas9 system for RNA-programmable genome editing by counterselection in the opportunistic human pathogen Streptococcus pneumoniae Specifically, we demonstrate an approach for making targeted markerless …
Here, we developed a replicative plasmid that carries the CRISPR-Cas9 system for RNA-programmable genome editing by countersel …
Unraveling the potential of CRISPR-Cas9 for gene therapy.
Barrangou R, May AP. Barrangou R, et al. Expert Opin Biol Ther. 2015 Mar;15(3):311-4. doi: 10.1517/14712598.2015.994501. Epub 2014 Dec 23. Expert Opin Biol Ther. 2015. PMID: 25535790
The molecular machinery from the prokaryotic clustered regularly interspaced short palindromic repeats (CRISPR)-Cas immune system has broadly been repurposed for genome editing in eukaryotes. In particular, the sequence-specific Cas9 endonuclease can be flexibly harness …
The molecular machinery from the prokaryotic clustered regularly interspaced short palindromic repeats (CRISPR)-Cas immune system has …
CRISPR-Cas9: A Potent Gene-editing Tool for the Treatment of Cancer.
Mishra G, Srivastava K, Rais J, Dixit M, Kumari Singh V, Chandra Mishra L. Mishra G, et al. Curr Mol Med. 2024;24(2):191-204. doi: 10.2174/1566524023666230213094308. Curr Mol Med. 2024. PMID: 36788695 Review.
The prokaryotic adaptive immune system has clustered regularly interspaced short palindromic repeat. CRISPR-associated protein (CRISPR-Cas) genome editing systems have been harnessed. ...In addition, CRISPR-Cas9 can combat oncogenic infections and test …
The prokaryotic adaptive immune system has clustered regularly interspaced short palindromic repeat. CRISPR-associated protein (CRISP …
Engineering disease resistant plants through CRISPR-Cas9 technology.
Tyagi S, Kumar R, Kumar V, Won SY, Shukla P. Tyagi S, et al. GM Crops Food. 2021 Jan 2;12(1):125-144. doi: 10.1080/21645698.2020.1831729. GM Crops Food. 2021. PMID: 33079628 Free PMC article. Review.
In this context, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) has transformed genome editing (GE) technology and being harnessed for altering the traits. Here we have summarized the complexities of plant immune …
In this context, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) has transformed genom …
Harnessing CRISPR/Cas9 for Enhanced Disease Resistance in Hot Peppers: A Comparative Study on CaMLO2-Gene-Editing Efficiency across Six Cultivars.
Park JH, Kim H. Park JH, et al. Int J Mol Sci. 2023 Nov 26;24(23):16775. doi: 10.3390/ijms242316775. Int J Mol Sci. 2023. PMID: 38069102 Free PMC article.
Recent advancements in genome editing, particularly using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9, have unlocked unprecedented opportunities for modifying disease-resistant genes and improving crop characteristics. ...This study addre …
Recent advancements in genome editing, particularly using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 …
47 results