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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. Harper JW, et al. Cell. 1993 Nov 19;75(4):805-16. doi: 10.1016/0092-8674(93)90499-g. Cell. 1993. PMID: 8242751
The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27.
Wingate H, Zhang N, McGarhen MJ, Bedrosian I, Harper JW, Keyomarsi K. Wingate H, et al. Among authors: harper jw. J Biol Chem. 2005 Apr 15;280(15):15148-57. doi: 10.1074/jbc.M409789200. Epub 2005 Feb 10. J Biol Chem. 2005. PMID: 15708847
The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.
Wei Y, Jin J, Harper JW. Wei Y, et al. Among authors: harper jw. Mol Cell Biol. 2003 May;23(10):3669-80. doi: 10.1128/mcb.23.10.3669-3680.2003. Mol Cell Biol. 2003. PMID: 12724424 Free PMC article.
Cyclin F disruption compromises placental development and affects normal cell cycle execution.
Tetzlaff MT, Bai C, Finegold M, Wilson J, Harper JW, Mahon KA, Elledge SJ. Tetzlaff MT, et al. Among authors: harper jw. Mol Cell Biol. 2004 Mar;24(6):2487-98. doi: 10.1128/mcb.24.6.2487-2498.2004. Mol Cell Biol. 2004. PMID: 14993286 Free PMC article.
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JW. Xu L, et al. Among authors: harper jw. Nature. 2003 Sep 18;425(6955):316-21. doi: 10.1038/nature01985. Epub 2003 Sep 3. Nature. 2003. PMID: 13679922
Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ. Wang Y, et al. Among authors: harper jw. Cell. 2003 Mar 7;112(5):697-709. doi: 10.1016/s0092-8674(03)00121-1. Cell. 2003. PMID: 12628189
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
Yang G, Ayala G, De Marzo A, Tian W, Frolov A, Wheeler TM, Thompson TC, Harper JW. Yang G, et al. Among authors: harper jw. Clin Cancer Res. 2002 Nov;8(11):3419-26. Clin Cancer Res. 2002. PMID: 12429629
The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.
Ye X, Wei Y, Nalepa G, Harper JW. Ye X, et al. Among authors: harper jw. Mol Cell Biol. 2003 Dec;23(23):8586-600. doi: 10.1128/mcb.23.23.8586-8600.2003. Mol Cell Biol. 2003. PMID: 14612403 Free PMC article.
Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling.
Wang W, Ungermannova D, Jin J, Harper JW, Liu X. Wang W, et al. Among authors: harper jw. Oncogene. 2004 Feb 5;23(5):1064-75. doi: 10.1038/sj.onc.1207204. Oncogene. 2004. PMID: 14676846
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.
Hao B, Oehlmann S, Sowa ME, Harper JW, Pavletich NP. Hao B, et al. Among authors: harper jw. Mol Cell. 2007 Apr 13;26(1):131-43. doi: 10.1016/j.molcel.2007.02.022. Mol Cell. 2007. PMID: 17434132
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