Harraz Osama F - Search Results

Year	Number of Results
2009	1
2011	1
2012	2
2013	4
2014	3
2015	2
2016	1
2017	1
2018	4
2020	3
2021	7
2022	2
2023	5
2024	9
2025	7
2026	2

1

Translating cardiovascular ion channel and Ca²⁺ signalling mechanisms into therapeutic insights.

Marchianò S, Martín-Aragón Baudel M, Smith CER, Hernandez GH, Bers DM, Boyle PM, Dobrev D, Hamilton S, Harraz OF, Li N, Longden TA, Louch WE, Nieves-Cintron M, Nystoriak MA, Murfee WL, Radwański PB, Sonkusare SK, Navedo MF, Grandi E. Marchianò S, et al. Among authors: harraz of. J Physiol. 2026 Jan 28:10.1113/JP290180. doi: 10.1113/JP290180. Online ahead of print. J Physiol. 2026. PMID: 41605640 Free PMC article. Review.

2

PIP₂ corrects an endothelial Piezo1 channelopathy.

Hashad AM, Abd-Alhaseeb MM, Lim XR, Mathieu NM, Harraz OF. Hashad AM, et al. Among authors: harraz of. Proc Natl Acad Sci U S A. 2025 Dec 30;122(52):e2522750122. doi: 10.1073/pnas.2522750122. Epub 2025 Dec 23. Proc Natl Acad Sci U S A. 2025. PMID: 41433068 Free PMC article.

3

Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease.

Tabrizi Z, Lim XR, Chakraborty S, Harraz OF, Bracko O. Tabrizi Z, et al. Among authors: harraz of. Alzheimers Dement. 2025 Dec;21(12):e71016. doi: 10.1002/alz.71016. Alzheimers Dement. 2025. PMID: 41399123 Free PMC article.

4

VasoTracker 2: Open-source software and hardware for tracking blood vessel diameter and assessing vascular function.

Lee MD, Osborne C, Stevenson R, MacDonald A, Ebner G, Jeffrey DA, MacDonald MA, Zhang X, Buckley C, Dabertrand F, Machin DR, Au J, Harraz OF, Tykocki N, McCarron JG, Wilson C. Lee MD, et al. Among authors: harraz of. J Physiol. 2025 Nov;603(22):6763-6781. doi: 10.1113/JP289322. Epub 2025 Oct 19. J Physiol. 2025. PMID: 41110981 Free PMC article.

5

Brain Capillary Ion Channels: Physiology and Channelopathies.

Harraz OF, Hashad AM. Harraz OF, et al. Physiology (Bethesda). 2026 Jan 1;41(1):0. doi: 10.1152/physiol.00015.2025. Epub 2025 Aug 1. Physiology (Bethesda). 2026. PMID: 40748720 Free PMC article. Review.

6

Estrogen Enhances SK Channel Activity to Limit Hippocampal Arteriole Constriction.

Jeffrey DA, Russell AN, Ferris HR, Romero PZ, Bueno Guerrero M, Fontaine JT, Hashad AM, Bolt MA, Fosdick BK, Rosehart AC, Harraz OF, Dabertrand F. Jeffrey DA, et al. Among authors: harraz of. Circ Res. 2025 Aug;137(4):456-470. doi: 10.1161/CIRCRESAHA.125.326631. Epub 2025 Jun 26. Circ Res. 2025. PMID: 40567232 Free article.

7

A computational framework for quantifying blood flow dynamics across myogenically-active cerebral arterial networks.

Coccarelli A, Polydoros I, Drysdale A, Harraz OF, Kadapa C. Coccarelli A, et al. Among authors: harraz of. Biomech Model Mechanobiol. 2025 Jun;24(3):1123-1140. doi: 10.1007/s10237-025-01958-3. Epub 2025 May 9. Biomech Model Mechanobiol. 2025. PMID: 40343574 Free PMC article.

8

Amyloid beta Aβ_1-40 activates Piezo1 channels in brain capillary endothelial cells.

Lim XR, Willemse L, Harraz OF. Lim XR, et al. Among authors: harraz of. Biophys J. 2025 Dec 16;124(24):4432-4441. doi: 10.1016/j.bpj.2024.12.025. Epub 2024 Dec 24. Biophys J. 2025. PMID: 39722451

9

A new computational model for quantifying blood flow dynamics across myogenically-active cerebral arterial networks.

Coccarelli A, Polydoros I, Drysdale A, Harraz OF, Kadapa C. Coccarelli A, et al. Among authors: harraz of. ArXiv [Preprint]. 2024 Nov 13:arXiv:2411.09046v1. ArXiv. 2024. Update in: Biomech Model Mechanobiol. 2025 Jun;24(3):1123-1140. doi: 10.1007/s10237-025-01958-3. PMID: 39606730 Free PMC article. Updated. Preprint.

10

Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow.

Lim XR, Abd-Alhaseeb MM, Ippolito M, Koide M, Senatore AJ, Plante C, Hariharan A, Weir N, Longden TA, Laprade KA, Stafford JM, Ziemens D, Schwaninger M, Wenzel J, Postnov DD, Harraz OF. Lim XR, et al. Among authors: harraz of. Nat Commun. 2024 Oct 7;15(1):8686. doi: 10.1038/s41467-024-52969-0. Nat Commun. 2024. PMID: 39375369 Free PMC article.

11

Evidence of an excitatory purinergic innervation in mouse corpus cavernosum smooth muscle.

Lim XR, Mercer M, Harraz OF, Hollywood MA, Sergeant GP, Thornbury KD. Lim XR, et al. Among authors: harraz of. J Sex Med. 2024 Oct 31;21(11):977-985. doi: 10.1093/jsxmed/qdae107. J Sex Med. 2024. PMID: 39234981

12

Distinct potassium channel types in brain capillary pericytes.

Sancho M, Klug NR, Harraz OF, Hill-Eubanks D, Nelson MT. Sancho M, et al. Among authors: harraz of. Biophys J. 2024 Jul 16;123(14):2110-2121. doi: 10.1016/j.bpj.2024.03.004. Epub 2024 Mar 5. Biophys J. 2024. PMID: 38444160 Free PMC article.

13

Correction to: A new model for evaluating pressure‑induced vascular tone in small cerebral arteries.

Coccarelli A, Pant S, Polydoros I, Harraz OF. Coccarelli A, et al. Among authors: harraz of. Biomech Model Mechanobiol. 2024 Apr;23(2):707. doi: 10.1007/s10237-023-01795-2. Biomech Model Mechanobiol. 2024. PMID: 38358396 Free PMC article. No abstract available.

14

A new model for evaluating pressure-induced vascular tone in small cerebral arteries.

Coccarelli A, Pant S, Polydoros I, Harraz OF. Coccarelli A, et al. Among authors: harraz of. Biomech Model Mechanobiol. 2024 Feb;23(1):271-286. doi: 10.1007/s10237-023-01774-7. Epub 2023 Nov 4. Biomech Model Mechanobiol. 2024. PMID: 37925376 Free PMC article.

15

Mechanosensing by Vascular Endothelium.

Lim XR, Harraz OF. Lim XR, et al. Among authors: harraz of. Annu Rev Physiol. 2024 Feb 12;86:71-97. doi: 10.1146/annurev-physiol-042022-030946. Epub 2023 Oct 20. Annu Rev Physiol. 2024. PMID: 37863105 Free PMC article. Review.

16

Recent insights into channelopathies.

Harraz OF, Delpire E. Harraz OF, et al. Physiol Rev. 2024 Jan 1;104(1):23-31. doi: 10.1152/physrev.00022.2023. Epub 2023 Aug 10. Physiol Rev. 2024. PMID: 37561136 Free article. No abstract available.

17

Endothelial Cell Metabolism and Vascular Function: A Paradigm Shift?

Harraz OF. Harraz OF. Function (Oxf). 2023 Jan 6;4(2):zqad002. doi: 10.1093/function/zqad002. eCollection 2023. Function (Oxf). 2023. PMID: 36778750 Free PMC article. No abstract available.

18

Diversity of cells and signals in the cardiovascular system.

Grandi E, Navedo MF, Saucerman JJ, Bers DM, Chiamvimonvat N, Dixon RE, Dobrev D, Gomez AM, Harraz OF, Hegyi B, Jones DK, Krogh-Madsen T, Murfee WL, Nystoriak MA, Posnack NG, Ripplinger CM, Veeraraghavan R, Weinberg S. Grandi E, et al. Among authors: harraz of. J Physiol. 2023 Jul;601(13):2547-2592. doi: 10.1113/JP284011. Epub 2023 Feb 16. J Physiol. 2023. PMID: 36744541 Free PMC article.

19

Editorial: Small and mighty: Brain capillaries in health and disease.

Bracko O, Harraz OF. Bracko O, et al. Among authors: harraz of. Front Mol Neurosci. 2022 Dec 13;15:1108978. doi: 10.3389/fnmol.2022.1108978. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36583082 Free PMC article. No abstract available.

20

Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries.

Harraz OF, Klug NR, Senatore AJ, Hill-Eubanks DC, Nelson MT. Harraz OF, et al. Circ Res. 2022 May 13;130(10):1531-1546. doi: 10.1161/CIRCRESAHA.122.320827. Epub 2022 Apr 6. Circ Res. 2022. PMID: 35382561 Free PMC article.

21

Vascular calcium signalling and ageing.

Harraz OF, Jensen LJ. Harraz OF, et al. J Physiol. 2021 Dec;599(24):5361-5377. doi: 10.1113/JP280950. Epub 2021 Nov 21. J Physiol. 2021. PMID: 34705288 Free PMC article. Review.

22

Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels.

Sackheim AM, Villalba N, Sancho M, Harraz OF, Bonev AD, D'Alessandro A, Nemkov T, Nelson MT, Freeman K. Sackheim AM, et al. Among authors: harraz of. Function (Oxf). 2021;2(3):zqab018. doi: 10.1093/function/zqab018. Epub 2021 Apr 6. Function (Oxf). 2021. PMID: 34568829 Free PMC article.

23

Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease.

Koide M, Harraz OF, Dabertrand F, Longden TA, Ferris HR, Wellman GC, Hill-Eubanks DC, Greenstein AS, Nelson MT. Koide M, et al. Among authors: harraz of. J Clin Invest. 2021 Sep 15;131(18):e149029. doi: 10.1172/JCI149029. J Clin Invest. 2021. PMID: 34351870 Free PMC article.

24

Local IP₃ receptor-mediated Ca²⁺ signals compound to direct blood flow in brain capillaries.

Longden TA, Mughal A, Hennig GW, Harraz OF, Shui B, Lee FK, Lee JC, Reining S, Kotlikoff MI, König GM, Kostenis E, Hill-Eubanks D, Nelson MT. Longden TA, et al. Among authors: harraz of. Sci Adv. 2021 Jul 21;7(30):eabh0101. doi: 10.1126/sciadv.abh0101. Print 2021 Jul. Sci Adv. 2021. PMID: 34290098 Free PMC article.

25

Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle.

Betrie AH, Brock JA, Harraz OF, Bush AI, He GW, Nelson MT, Angus JA, Wright CE, Ayton S. Betrie AH, et al. Among authors: harraz of. Nat Commun. 2021 Jun 1;12(1):3296. doi: 10.1038/s41467-021-23198-6. Nat Commun. 2021. PMID: 34075043 Free PMC article.

26

PIP₂ corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity.

Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT. Dabertrand F, et al. Among authors: harraz of. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2025998118. doi: 10.1073/pnas.2025998118. Proc Natl Acad Sci U S A. 2021. PMID: 33875602 Free PMC article.

27

PIP₂ Improves Cerebral Blood Flow in a Mouse Model of Alzheimer's Disease.

Mughal A, Harraz OF, Gonzales AL, Hill-Eubanks D, Nelson MT. Mughal A, et al. Among authors: harraz of. Function (Oxf). 2021 Feb 22;2(2):zqab010. doi: 10.1093/function/zqab010. eCollection 2021. Function (Oxf). 2021. PMID: 33763649 Free PMC article.

28

Aging, calcium channel signaling and vascular tone.

Harraz OF, Jensen LJ. Harraz OF, et al. Mech Ageing Dev. 2020 Oct;191:111336. doi: 10.1016/j.mad.2020.111336. Epub 2020 Sep 9. Mech Ageing Dev. 2020. PMID: 32918949 Free PMC article. Review.

29

PIP₂: A critical regulator of vascular ion channels hiding in plain sight.

Harraz OF, Hill-Eubanks D, Nelson MT. Harraz OF, et al. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20378-20389. doi: 10.1073/pnas.2006737117. Epub 2020 Aug 6. Proc Natl Acad Sci U S A. 2020. PMID: 32764146 Free PMC article. Review.

30

The capillary Kir channel as sensor and amplifier of neuronal signals: Modeling insights on K⁺-mediated neurovascular communication.

Moshkforoush A, Ashenagar B, Harraz OF, Dabertrand F, Longden TA, Nelson MT, Tsoukias NM. Moshkforoush A, et al. Among authors: harraz of. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16626-16637. doi: 10.1073/pnas.2000151117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601236 Free PMC article.

31

TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw.

Gomes CC, Gayden T, Bajic A, Harraz OF, Pratt J, Nikbakht H, Bareke E, Diniz MG, Castro WH, St-Onge P, Sinnett D, Han H, Rivera B, Mikael LG, De Jay N, Kleinman CL, Valera ET, Bassenden AV, Berghuis AM, Majewski J, Nelson MT, Gomez RS, Jabado N. Gomes CC, et al. Among authors: harraz of. Nat Commun. 2018 Nov 1;9(1):4572. doi: 10.1038/s41467-018-06690-4. Nat Commun. 2018. PMID: 30385747 Free PMC article.

32

Caveolae Link Ca_V3.2 Channels to BK_Ca-Mediated Feedback in Vascular Smooth Muscle.

Hashad AM, Harraz OF, Brett SE, Romero M, Kassmann M, Puglisi JL, Wilson SM, Gollasch M, Welsh DG. Hashad AM, et al. Among authors: harraz of. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2371-2381. doi: 10.1161/ATVBAHA.118.311394. Arterioscler Thromb Vasc Biol. 2018. PMID: 30354206

33

PIP₂ depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells.

Harraz OF, Longden TA, Hill-Eubanks D, Nelson MT. Harraz OF, et al. Elife. 2018 Aug 7;7:e38689. doi: 10.7554/eLife.38689. Elife. 2018. PMID: 30084828 Free PMC article.

34

Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP₂ depletion.

Harraz OF, Longden TA, Dabertrand F, Hill-Eubanks D, Nelson MT. Harraz OF, et al. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3569-E3577. doi: 10.1073/pnas.1800201115. Epub 2018 Mar 26. Proc Natl Acad Sci U S A. 2018. PMID: 29581272 Free PMC article.

35

Interplay among distinct Ca²⁺ conductances drives Ca²⁺ sparks/spontaneous transient outward currents in rat cerebral arteries.

Hashad AM, Mazumdar N, Romero M, Nygren A, Bigdely-Shamloo K, Harraz OF, Puglisi JL, Vigmond EJ, Wilson SM, Welsh DG. Hashad AM, et al. Among authors: harraz of. J Physiol. 2017 Feb 15;595(4):1111-1126. doi: 10.1113/JP273329. Epub 2016 Dec 12. J Physiol. 2017. PMID: 27805790 Free PMC article.

36

Genetic ablation of CaV3.2 channels enhances the arterial myogenic response by modulating the RyR-BKCa axis.

Harraz OF, Brett SE, Zechariah A, Romero M, Puglisi JL, Wilson SM, Welsh DG. Harraz OF, et al. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1843-51. doi: 10.1161/ATVBAHA.115.305736. Epub 2015 Jun 11. Arterioscler Thromb Vasc Biol. 2015. PMID: 26069238 Free PMC article.

37

CaV1.2/CaV3.x channels mediate divergent vasomotor responses in human cerebral arteries.

Harraz OF, Visser F, Brett SE, Goldman D, Zechariah A, Hashad AM, Menon BK, Watson T, Starreveld Y, Welsh DG. Harraz OF, et al. J Gen Physiol. 2015 May;145(5):405-18. doi: 10.1085/jgp.201511361. J Gen Physiol. 2015. PMID: 25918359 Free PMC article.

38

Ca(V)3.2 channels and the induction of negative feedback in cerebral arteries.

Harraz OF, Abd El-Rahman RR, Bigdely-Shamloo K, Wilson SM, Brett SE, Romero M, Gonzales AL, Earley S, Vigmond EJ, Nygren A, Menon BK, Mufti RE, Watson T, Starreveld Y, Furstenhaupt T, Muellerleile PR, Kurjiaka DT, Kyle BD, Braun AP, Welsh DG. Harraz OF, et al. Circ Res. 2014 Sep 12;115(7):650-61. doi: 10.1161/CIRCRESAHA.114.304056. Epub 2014 Aug 1. Circ Res. 2014. PMID: 25085940 Free PMC article.

39

STIM1-mediated bidirectional regulation of Ca(2+) entry through voltage-gated calcium channels (VGCC) and calcium-release activated channels (CRAC).

Harraz OF, Altier C. Harraz OF, et al. Front Cell Neurosci. 2014 Feb 24;8:43. doi: 10.3389/fncel.2014.00043. eCollection 2014. Front Cell Neurosci. 2014. PMID: 24605083 Free PMC article. Review.

40

Nitric oxide suppresses vascular voltage-gated T-type Ca2+ channels through cGMP/PKG signaling.

Harraz OF, Brett SE, Welsh DG. Harraz OF, et al. Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H279-85. doi: 10.1152/ajpheart.00743.2013. Epub 2013 Nov 15. Am J Physiol Heart Circ Physiol. 2014. PMID: 24240871 Free article.

41

Protein kinase A regulation of T-type Ca2+ channels in rat cerebral arterial smooth muscle.

Harraz OF, Welsh DG. Harraz OF, et al. J Cell Sci. 2013 Jul 1;126(Pt 13):2944-54. doi: 10.1242/jcs.128363. Epub 2013 Apr 23. J Cell Sci. 2013. PMID: 23613468

42

T-type Ca²⁺ channels in cerebral arteries: approaches, hypotheses, and speculation.

Harraz OF, Welsh DG. Harraz OF, et al. Microcirculation. 2013 May;20(4):299-306. doi: 10.1111/micc.12038. Microcirculation. 2013. PMID: 23331671 Review.

43

Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development.

Abd El-Rahman RR, Harraz OF, Brett SE, Anfinogenova Y, Mufti RE, Goldman D, Welsh DG. Abd El-Rahman RR, et al. Among authors: harraz of. Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H58-71. doi: 10.1152/ajpheart.00476.2012. Epub 2012 Oct 26. Am J Physiol Heart Circ Physiol. 2013. PMID: 23103495 Free PMC article.

44

Adenosinergic modulation of the imidazoline I₁-receptor-dependent hypotensive effect of ethanol in acute renal failure.

Harraz OF, El-Gowelli HM, Mohy El-Din MM, Ghazal AR, El-Mas MM. Harraz OF, et al. Food Chem Toxicol. 2012 Aug;50(8):2622-8. doi: 10.1016/j.fct.2012.05.015. Epub 2012 May 18. Food Chem Toxicol. 2012. PMID: 22613216

45

Do TRPC-like currents and G protein-coupled receptors interact to facilitate myogenic tone development?

Anfinogenova Y, Brett SE, Walsh MP, Harraz OF, Welsh DG. Anfinogenova Y, et al. Among authors: harraz of. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1378-88. doi: 10.1152/ajpheart.00460.2011. Epub 2011 Aug 5. Am J Physiol Heart Circ Physiol. 2011. PMID: 21821777 Free article.

46

Facilitation of central imidazoline I(1)-site/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase signalling mediates the hypotensive effect of ethanol in rats with acute renal failure.

El-Mas MM, El-Gowelli HM, Ghazal AR, Harraz OF, Mohy El-Din MM. El-Mas MM, et al. Among authors: harraz of. Br J Pharmacol. 2009 Nov;158(6):1629-40. doi: 10.1111/j.1476-5381.2009.00444.x. Epub 2009 Oct 20. Br J Pharmacol. 2009. PMID: 19845670 Free PMC article.

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