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Human pharmacology of the methamphetamine stereoisomers.
Mendelson J, Uemura N, Harris D, Nath RP, Fernandez E, Jacob P 3rd, Everhart ET, Jones RT. Mendelson J, et al. Among authors: Harris D. Clin Pharmacol Ther. 2006 Oct;80(4):403-20. doi: 10.1016/j.clpt.2006.06.013. Clin Pharmacol Ther. 2006. PMID: 17015058 Clinical Trial.
After racemate administration, the AUC for d-methamphetamine was 30% smaller than that for l-methamphetamine (P = .0085). The elimination half-lives were longer for l-methamphetamine (13.3-15.0 hours) than for d-methamphetamine (10.2-10.7 hours) (P < .0001). ...Racemic and d-methamphetamine have similar effects and would be expected to have comparable abuse liabilities....
After racemate administration, the AUC for d-methamphetamine was 30% smaller than that for l-methamphetamine (P = .0085). The elimina …
The clinical pharmacology of intranasal l-methamphetamine.
Mendelson JE, McGlothlin D, Harris DS, Foster E, Everhart T, Jacob P 3rd, Jones RT. Mendelson JE, et al. Among authors: Harris DS. BMC Clin Pharmacol. 2008 Jul 21;8:4. doi: 10.1186/1472-6904-8-4. BMC Clin Pharmacol. 2008. PMID: 18644153 Free PMC article.
Repeated psychological stress testing in stimulant-dependent patients.
Harris DS, Reus VI, Wolkowitz OM, Mendelson JE, Jones RT. Harris DS, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):669-77. doi: 10.1016/j.pnpbp.2005.04.012. Prog Neuropsychopharmacol Biol Psychiatry. 2005. PMID: 15913869 Clinical Trial.
The pharmacology of cocaethylene in humans following cocaine and ethanol administration.
Harris DS, Everhart ET, Mendelson J, Jones RT. Harris DS, et al. Drug Alcohol Depend. 2003 Nov 24;72(2):169-82. doi: 10.1016/s0376-8716(03)00200-x. Drug Alcohol Depend. 2003. PMID: 14636972 Clinical Trial.
A small (7.5 mg) nonpharmacologically active dose of deuterium-labeled cocaethylene-d(3) was concurrently administered with the cocaine to enable calculation of absolute cocaethylene formation and clearance. ...RESULTS: When co-administered with ethanol, 17+/-6% (mean+/-S.D.) of the cocaine was converted to cocaethylene. Cocaethylene peak plasma concentrations and AUC increased proportionally to the cocaine dose. ...
A small (7.5 mg) nonpharmacologically active dose of deuterium-labeled cocaethylene-d(3) was concurrently administered with the cocai …
The bioavailability of intranasal and smoked methamphetamine.
Harris DS, Boxenbaum H, Everhart ET, Sequeira G, Mendelson JE, Jones RT. Harris DS, et al. Clin Pharmacol Ther. 2003 Nov;74(5):475-86. doi: 10.1016/j.clpt.2003.08.002. Clin Pharmacol Ther. 2003. PMID: 14586388 Clinical Trial.
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