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Molecular pathogenesis of ADPKD: the polycystin complex gets complex.
Ong AC, Harris PC. Ong AC, et al. Kidney Int. 2005 Apr;67(4):1234-47. doi: 10.1111/j.1523-1755.2005.00201.x. Kidney Int. 2005. PMID: 15780076
Polycystin-1 expression in PKD1, early-onset PKD1, and TSC2/PKD1 cystic tissue.
Ong AC, Harris PC, Davies DR, Pritchard L, Rossetti S, Biddolph S, Vaux DJ, Migone N, Ward CJ. Ong AC, et al. Kidney Int. 1999 Oct;56(4):1324-33. doi: 10.1046/j.1523-1755.1999.00659.x. Kidney Int. 1999. PMID: 10504485
The position of the polycystic kidney disease 1 (PKD1) gene mutation correlates with the severity of renal disease.
Rossetti S, Burton S, Strmecki L, Pond GR, San Millán JL, Zerres K, Barratt TM, Ozen S, Torres VE, Bergstralh EJ, Winearls CG, Harris PC. Rossetti S, et al. J Am Soc Nephrol. 2002 May;13(5):1230-7. doi: 10.1097/01.asn.0000013300.11876.37. J Am Soc Nephrol. 2002. PMID: 11961010
A complete mutation screen of the ADPKD genes by DHPLC.
Rossetti S, Chauveau D, Walker D, Saggar-Malik A, Winearls CG, Torres VE, Harris PC. Rossetti S, et al. Kidney Int. 2002 May;61(5):1588-99. doi: 10.1046/j.1523-1755.2002.00326.x. Kidney Int. 2002. PMID: 11967008
Molecular basis of polycystic kidney disease: PKD1, PKD2 and PKHD1.
Harris PC. Harris PC. Curr Opin Nephrol Hypertens. 2002 May;11(3):309-14. doi: 10.1097/00041552-200205000-00007. Curr Opin Nephrol Hypertens. 2002. PMID: 11981261 Review.
Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.
Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T, Kurabayashi M, Nagai R, Higashihara E, Harris PC, Katsuki M, Horie S. Muto S, et al. Hum Mol Genet. 2002 Jul 15;11(15):1731-42. doi: 10.1093/hmg/11.15.1731. Hum Mol Genet. 2002. PMID: 12095915
Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype.
Rossetti S, Chauveau D, Kubly V, Slezak JM, Saggar-Malik AK, Pei Y, Ong AC, Stewart F, Watson ML, Bergstralh EJ, Winearls CG, Torres VE, Harris PC. Rossetti S, et al. Lancet. 2003 Jun 28;361(9376):2196-201. doi: 10.1016/S0140-6736(03)13773-7. Lancet. 2003. PMID: 12842373 Clinical Trial.
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