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Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis.
Yanagi KS, Wu Z, Amaya J, Chapkis N, Duffy AM, Hajdarovic KH, Held A, Mathur AD, Russo K, Ryan VH, Steinert BL, Whitt JP, Fallon JR, Fawzi NL, Lipscombe D, Reenan RA, Wharton KA, Hart AC. Yanagi KS, et al. Among authors: hart ac. Neuroscience. 2019 Jan 1;396:A3-A20. doi: 10.1016/j.neuroscience.2018.10.033. Neuroscience. 2019. PMID: 30594291 Free PMC article.
Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.
Baskoylu SN, Yersak J, O'Hern P, Grosser S, Simon J, Kim S, Schuch K, Dimitriadi M, Yanagi KS, Lins J, Hart AC. Baskoylu SN, et al. Among authors: hart ac. PLoS Genet. 2018 Oct 8;14(10):e1007682. doi: 10.1371/journal.pgen.1007682. eCollection 2018 Oct. PLoS Genet. 2018. PMID: 30296255 Free PMC article.
Conserved genes act as modifiers of invertebrate SMN loss of function defects.
Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC. Dimitriadi M, et al. Among authors: hart ac. PLoS Genet. 2010 Oct 28;6(10):e1001172. doi: 10.1371/journal.pgen.1001172. PLoS Genet. 2010. PMID: 21124729 Free PMC article.
104 results