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Mitotane has a strong and a durable inducing effect on CYP3A4 activity.
van Erp NP, Guchelaar HJ, Ploeger BA, Romijn JA, Hartigh Jd, Gelderblom H. van Erp NP, et al. Among authors: hartigh jd. Eur J Endocrinol. 2011 Apr;164(4):621-6. doi: 10.1530/EJE-10-0956. Epub 2011 Jan 10. Eur J Endocrinol. 2011. PMID: 21220434 Clinical Trial.
Development of a nose cream containing the synthetic antimicrobial peptide P60.4Ac for eradication of methicillin-resistant Staphylococcus aureus carriage.
Göblyös A, Schimmel KJ, Valentijn AR, Fathers LM, Cordfunke RA, Chan HL, Oostendorp J, Nibbering PH, Drijfhout JW, Hiemstra PS, Hartigh JD. Göblyös A, et al. Among authors: hartigh jd. J Pharm Sci. 2013 Oct;102(10):3539-44. doi: 10.1002/jps.23695. Epub 2013 Aug 17. J Pharm Sci. 2013. PMID: 23955373
A validated assay for the simultaneous quantification of six tyrosine kinase inhibitors and two active metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.
van Erp NP, de Wit D, Guchelaar HJ, Gelderblom H, Hessing TJ, Hartigh Jd. van Erp NP, et al. Among authors: hartigh jd. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 15;937:33-43. doi: 10.1016/j.jchromb.2013.08.013. Epub 2013 Aug 17. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 24013127