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In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.
Obermann WM, Sondermann H, Russo AA, Pavletich NP, Hartl FU. Obermann WM, et al. J Cell Biol. 1998 Nov 16;143(4):901-10. doi: 10.1083/jcb.143.4.901. J Cell Biol. 1998. PMID: 9817749 Free PMC article.
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity.
Sakahira H, Breuer P, Hayer-Hartl MK, Hartl FU. Sakahira H, et al. Proc Natl Acad Sci U S A. 2002 Dec 10;99 Suppl 4(Suppl 4):16412-8. doi: 10.1073/pnas.182426899. Epub 2002 Aug 20. Proc Natl Acad Sci U S A. 2002. PMID: 12189209 Free PMC article. Review.
The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation.
Rosenhagen MC, Sōti C, Schmidt U, Wochnik GM, Hartl FU, Holsboer F, Young JC, Rein T. Rosenhagen MC, et al. Mol Endocrinol. 2003 Oct;17(10):1991-2001. doi: 10.1210/me.2003-0141. Epub 2003 Jul 17. Mol Endocrinol. 2003. PMID: 12869591
Roles of molecular chaperones in protein misfolding diseases.
Barral JM, Broadley SA, Schaffar G, Hartl FU. Barral JM, et al. Semin Cell Dev Biol. 2004 Feb;15(1):17-29. doi: 10.1016/j.semcdb.2003.12.010. Semin Cell Dev Biol. 2004. PMID: 15036203 Review.
Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli.
Kerner MJ, Naylor DJ, Ishihama Y, Maier T, Chang HC, Stines AP, Georgopoulos C, Frishman D, Hayer-Hartl M, Mann M, Hartl FU. Kerner MJ, et al. Cell. 2005 Jul 29;122(2):209-20. doi: 10.1016/j.cell.2005.05.028. Cell. 2005. PMID: 16051146
Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.
Haacke A, Broadley SA, Boteva R, Tzvetkov N, Hartl FU, Breuer P. Haacke A, et al. Hum Mol Genet. 2006 Feb 15;15(4):555-68. doi: 10.1093/hmg/ddi472. Epub 2006 Jan 11. Hum Mol Genet. 2006. PMID: 16407371
Identification of nascent chain interaction sites on trigger factor.
Lakshmipathy SK, Tomic S, Kaiser CM, Chang HC, Genevaux P, Georgopoulos C, Barral JM, Johnson AE, Hartl FU, Etchells SA. Lakshmipathy SK, et al. J Biol Chem. 2007 Apr 20;282(16):12186-93. doi: 10.1074/jbc.M609871200. Epub 2007 Feb 12. J Biol Chem. 2007. PMID: 17296610
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