Hartmann G - Search Results

1

Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice.

Hartmann G, Kim H, Piquette-Miller M. Hartmann G, et al. Int Immunopharmacol. 2001 Feb;1(2):189-99. doi: 10.1016/s0162-3109(00)00271-x. Int Immunopharmacol. 2001. PMID: 11360920

2

Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia.

Hartmann G, Cheung AK, Piquette-Miller M. Hartmann G, et al. J Pharmacol Exp Ther. 2002 Oct;303(1):273-81. doi: 10.1124/jpet.102.039404. J Pharmacol Exp Ther. 2002. PMID: 12235261

3

Impact of endotoxin-induced changes in P-glycoprotein expression on disposition of doxorubicin in mice.

Hartmann G, Vassileva V, Piquette-Miller M. Hartmann G, et al. Drug Metab Dispos. 2005 Jun;33(6):820-8. doi: 10.1124/dmd.104.002568. Epub 2005 Mar 18. Drug Metab Dispos. 2005. PMID: 15778272

4

Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.

Gilmore WJ, Hartmann G, Piquette-Miller M, Marriott J, Kirby GM. Gilmore WJ, et al. Among authors: hartmann g. Toxicology. 2003 Mar 3;184(2-3):211-26. doi: 10.1016/s0300-483x(02)00581-4. Toxicology. 2003. PMID: 12499123

5

Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.

Goralski KB, Hartmann G, Piquette-Miller M, Renton KW. Goralski KB, et al. Among authors: hartmann g. Br J Pharmacol. 2003 May;139(1):35-48. doi: 10.1038/sj.bjp.0705227. Br J Pharmacol. 2003. PMID: 12746221 Free PMC article.

6

Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice.

Hartmann G, Kumar S, Johns D, Gheyas F, Gutstein D, Shen X, Burton A, Lederman H, Lutz R, Jackson T, Chavez-Eng C, Mitra K. Hartmann G, et al. Drug Metab Dispos. 2016 Mar;44(3):428-34. doi: 10.1124/dmd.115.067736. Epub 2015 Dec 28. Drug Metab Dispos. 2016. PMID: 26712818

7

Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys.

Tan EY, Hartmann G, Chen Q, Pereira A, Bradley S, Doss G, Zhang AS, Ho JZ, Braun MP, Dean DC, Tang W, Kumar S. Tan EY, et al. Among authors: hartmann g. Drug Metab Dispos. 2010 Mar;38(3):459-73. doi: 10.1124/dmd.109.028696. Epub 2009 Dec 16. Drug Metab Dispos. 2010. PMID: 20016052

8

Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans.

Kumar S, Tan EY, Hartmann G, Biddle Z, Bergman AJ, Dru J, Ho JZ, Jones AN, Staskiewicz SJ, Braun MP, Karanam B, Dean DC, Gendrano IN, Graves MW, Wagner JA, Krishna R. Kumar S, et al. Among authors: hartmann g. Drug Metab Dispos. 2010 Mar;38(3):474-83. doi: 10.1124/dmd.109.028704. Epub 2009 Dec 16. Drug Metab Dispos. 2010. PMID: 20016053 Clinical Trial.

9

Characterization of Anacetrapib Distribution into the Lipid Droplet of Adipose Tissue in Mice and Human Cultured Adipocytes.

Johns DG, LeVoci L, Krsmanovic M, Lu M, Hartmann G, Xu S, Wang SP, Chen Y, Bateman T, Blaustein RO. Johns DG, et al. Among authors: hartmann g. Drug Metab Dispos. 2019 Mar;47(3):227-233. doi: 10.1124/dmd.118.084525. Epub 2018 Dec 19. Drug Metab Dispos. 2019. PMID: 30567880

10

Application of Physiologically Based Pharmacokinetic Modeling to Predict Pharmacokinetics in Healthy Japanese Subjects.

Matsumoto Y, Cabalu T, Sandhu P, Hartmann G, Iwasa T, Yoshitsugu H, Gibson C, Uemura N. Matsumoto Y, et al. Among authors: hartmann g. Clin Pharmacol Ther. 2019 Apr;105(4):1018-1030. doi: 10.1002/cpt.1240. Epub 2018 Dec 4. Clin Pharmacol Ther. 2019. PMID: 30252941 Free PMC article. Clinical Trial.

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