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Spermine prevents endonuclease activation and apoptosis in thymocytes.
Brüne B, Hartzell P, Nicotera P, Orrenius S. Brüne B, et al. Exp Cell Res. 1991 Aug;195(2):323-9. doi: 10.1016/0014-4827(91)90380-d. Exp Cell Res. 1991. PMID: 1649056
2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.
McConkey DJ, Hartzell P, Duddy SK, Håkansson H, Orrenius S. McConkey DJ, et al. Science. 1988 Oct 14;242(4876):256-9. doi: 10.1126/science.3262923. Science. 1988. PMID: 3262923
Suspensions of thymocytes from young rats were incubated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which resulted in a sustained increase in cytosolic free Ca2+ concentration followed by DNA fragmentation and loss of cell viability. ...
Suspensions of thymocytes from young rats were incubated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which resulted in a sustain …
Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration.
McConkey DJ, Nicotera P, Hartzell P, Bellomo G, Wyllie AH, Orrenius S. McConkey DJ, et al. Arch Biochem Biophys. 1989 Feb 15;269(1):365-70. doi: 10.1016/0003-9861(89)90119-7. Arch Biochem Biophys. 1989. PMID: 2537063
Calcium-activated DNA fragmentation kills immature thymocytes.
McConkey DJ, Hartzell P, Nicotera P, Orrenius S. McConkey DJ, et al. FASEB J. 1989 May;3(7):1843-9. doi: 10.1096/fasebj.3.7.2497041. FASEB J. 1989. PMID: 2497041
Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells.
McConkey DJ, Aguilar-Santelises M, Hartzell P, Eriksson I, Mellstedt H, Orrenius S, Jondal M. McConkey DJ, et al. J Immunol. 1991 Feb 1;146(3):1072-6. J Immunol. 1991. PMID: 1988495
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