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CYP3A4*16 and CYP3A4*18 alleles found in East Asians exhibit differential catalytic activities for seven CYP3A4 substrate drugs.
Maekawa K, Harakawa N, Yoshimura T, Kim SR, Fujimura Y, Aohara F, Sai K, Katori N, Tohkin M, Naito M, Hasegawa R, Okuda H, Sawada J, Niwa T, Saito Y. Maekawa K, et al. Drug Metab Dispos. 2010 Dec;38(12):2100-4. doi: 10.1124/dmd.110.034140. Epub 2010 Sep 16. Drug Metab Dispos. 2010. PMID: 20847137
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S, Kurose K, Saito Y, Ozawa S, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Nakajima T, Matsumoto K, Akasawa A, Saito H, Sawada J. Koyano S, et al. Drug Metab Dispos. 2004 Jan;32(1):149-54. doi: 10.1124/dmd.32.1.149. Drug Metab Dispos. 2004. PMID: 14709632
A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients.
Sai K, Kajinami K, Akao H, Iwadare M, Sato-Ishida R, Kawai Y, Takeda K, Tanimoto T, Yamano T, Akasaka T, Ishida T, Hirata KI, Saku K, Yagi S, Soeki T, Sata M, Ueno M, Miyazaki S, Shiraki A, Oyama JI, Node K, Sugamura K, Ogawa H, Kurose K, Maekawa K, Matsuzawa Y, Imatoh T, Hasegawa R; Japanese Pharmacogenomics Data Science Consortium, Saito Y. Sai K, et al. Drug Metab Pharmacokinet. 2016 Dec;31(6):467-470. doi: 10.1016/j.dmpk.2016.09.002. Epub 2016 Sep 17. Drug Metab Pharmacokinet. 2016. PMID: 27839692
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