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3,494 results
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The direct PAK1 inhibitor, TAT-PAK18, blocks preferentially the growth of human ovarian cancer cell lines in which PAK1 is abnormally activated by autophosphorylation at Thr 423.
Hashimoto H, Sudo T, Maruta H, Nishimura R. Hashimoto H, et al. Drug Discov Ther. 2010 Feb;4(1):1-4. Drug Discov Ther. 2010. PMID: 22491145
Recently we provided the first evidence indicating that an old antibiotic (antiparasitic drug) called Ivermectin suppresses the growth of a variety of human ovarian cancer cell lines in vitro by inactivating the oncogenic kinase PAK1 somehow (Hashimoto H, et al. Dru …
Recently we provided the first evidence indicating that an old antibiotic (antiparasitic drug) called Ivermectin suppresses the growth of a …
Ivermectin inactivates the kinase PAK1 and blocks the PAK1-dependent growth of human ovarian cancer and NF2 tumor cell lines.
Hashimoto H, Messerli SM, Sudo T, Maruta H. Hashimoto H, et al. Drug Discov Ther. 2009 Dec;3(6):243-6. Drug Discov Ther. 2009. PMID: 22495656
Digital PCR for determination of cytochrome P450 2D6 and sulfotransferase 1A1 gene copy number variations.
Motoi Y, Watanabe K, Honma H, Tadano Y, Hashimoto H, Kubota T. Motoi Y, et al. Among authors: hashimoto h. Drug Discov Ther. 2017;11(6):336-341. doi: 10.5582/ddt.2017.01057. Drug Discov Ther. 2017. PMID: 29332892
Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle-Brachial Index.
Maruhashi T, Kajikawa M, Kishimoto S, Hashimoto H, Takaeko Y, Yamaji T, Harada T, Hashimoto Y, Han Y, Aibara Y, Yusoff FM, Hidaka T, Chayama K, Nakashima A, Goto C, Kihara Y, Higashi Y. Maruhashi T, et al. Among authors: hashimoto h. J Am Heart Assoc. 2020 Nov 26:e017139. doi: 10.1161/JAHA.120.017139. Online ahead of print. J Am Heart Assoc. 2020. PMID: 33241751
Social policies and change in education-related disparities in mortality in Japan, 2000-2010.
Kasajima M, Hashimoto H. Kasajima M, et al. Among authors: hashimoto h. SSM Popul Health. 2020 Nov 7;12:100692. doi: 10.1016/j.ssmph.2020.100692. eCollection 2020 Dec. SSM Popul Health. 2020. PMID: 33241104 Free PMC article.
Eosinophilic infiltration discriminates lichen-planus-like eruption caused by an immune checkpoint inhibitor from ordinary lichen planus.
Hashimoto H, Ito T, Yamada Y, Oda Y, Furue M. Hashimoto H, et al. J Dermatol. 2020 Nov 21. doi: 10.1111/1346-8138.15705. Online ahead of print. J Dermatol. 2020. PMID: 33219712 No abstract available.
Antibiotic stewardship in critically ill patients with suspected ventilator-associated pneumonia.
Yoshimura J, Hashimoto H, Yamakawa K. Yoshimura J, et al. Among authors: hashimoto h. Ann Transl Med. 2020 Oct;8(20):1329. doi: 10.21037/atm-20-2421. Ann Transl Med. 2020. PMID: 33209909 Free PMC article. No abstract available.
Pyrexia by COVID-19 in a patient treated with dabrafenib/trametinib therapy.
Hashimoto H, Ito T, Ide T, Sasaki N, Hikichi S, Furue M. Hashimoto H, et al. J Dermatol. 2020 Nov 16. doi: 10.1111/1346-8138.15696. Online ahead of print. J Dermatol. 2020. PMID: 33200424 No abstract available.
Relationship between cell number and clinical outcomes of autologous bone-marrow mononuclear cell implantation in critical limb ischemia.
Yusoff FM, Kajikawa M, Takaeko Y, Kishimoto S, Hashimoto H, Maruhashi T, Nakashima A, Wahid SFSA, Higashi Y. Yusoff FM, et al. Among authors: hashimoto h. Sci Rep. 2020 Nov 16;10(1):19891. doi: 10.1038/s41598-020-76886-6. Sci Rep. 2020. PMID: 33199760 Free PMC article.
Locking versus nonlocking superior plate fixations for displaced midshaft clavicle fractures: A prospective randomized trial comparing clinical and radiografic results.
Uchiyama Y, Handa A, Omi H, Hashimoto H, Shimpuku E, Imai T, Takatori N, Watanabe M. Uchiyama Y, et al. Among authors: hashimoto h. J Orthop Sci. 2020 Nov 8:S0949-2658(20)30286-4. doi: 10.1016/j.jos.2020.09.017. Online ahead of print. J Orthop Sci. 2020. PMID: 33176960
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