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In vitro antibacterial activity and mechanism of action of J-111,225, a novel 1beta-methylcarbapenem, against transferable IMP-1 metallo-beta-lactamase producers.
Nagano R, Adachi Y, Hashizume T, Morishima H. Nagano R, et al. J Antimicrob Chemother. 2000 Mar;45(3):271-6. doi: 10.1093/jac/45.3.271. J Antimicrob Chemother. 2000. PMID: 10702544
Synthesis and antifungal activity of novel 14-membered benzomacrolides, as galbonolide analogues.
Sakoh H, Sakuraba S, Sugimoto Y, Imamura H, Jona H, Yamada K, Bamba-Nagano R, Hashizume T, Morishima H. Sakoh H, et al. Chem Pharm Bull (Tokyo). 2004 Jan;52(1):163-5. doi: 10.1248/cpb.52.163. Chem Pharm Bull (Tokyo). 2004. PMID: 14709890
Structure--activity relationships of 1beta-methyl-2-(5-phenylpyrrolidin-3-ylthio)carbapenems.
Sato H, Sakoh H, Hashihayata T, Imamura H, Ohtake N, Shimizu A, Sugimoto Y, Sakuraba S, Bamba-Nagano R, Yamada K, Hashizume T, Morishima H. Sato H, et al. Bioorg Med Chem. 2002 May;10(5):1595-610. doi: 10.1016/s0968-0896(01)00430-8. Bioorg Med Chem. 2002. PMID: 11886821
Novel galbonolide derivatives as IPC synthase inhibitors: design, synthesis and in vitro antifungal activities.
Sakoh H, Sugimoto Y, Imamura H, Sakuraba S, Jona H, Bamba-Nagano R, Yamada K, Hashizume T, Morishima H. Sakoh H, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):143-5. doi: 10.1016/j.bmcl.2003.09.072. Bioorg Med Chem Lett. 2004. PMID: 14684316
In vitro and in vivo evaluation of BO-2727 against imipenem- and/or meropenem-resistant Pseudomonas aeruginosa.
Shibata K, Adachi Y, Kato E, Nagano R, Fuse A, Hashizume T, Ohtake N, Okamoto O, Nakagawa S. Shibata K, et al. J Antibiot (Tokyo). 1997 Feb;50(2):135-8. doi: 10.7164/antibiotics.50.135. J Antibiot (Tokyo). 1997. PMID: 9099222
A novel 1beta-methylcarbapenem, J-111,225: effects of the C-3 and C-5 stereochemistry of the pyrrolidinylthio side chain on antibacterial activities.
Imamura H, Shimizu A, Sato H, Sugimoto Y, Sakuraba S, Nagano R, Yamada K, Hashizume T, Morishima H. Imamura H, et al. J Antibiot (Tokyo). 2000 Mar;53(3):314-6. doi: 10.7164/antibiotics.53.314. J Antibiot (Tokyo). 2000. PMID: 10819306 No abstract available.
Kinetic studies on the inhibition of Proteus vulgaris beta-lactamase by imipenem.
Hashizume T, Yamaguchi A, Hirata T, Sawai T. Hashizume T, et al. Antimicrob Agents Chemother. 1984 Jan;25(1):149-51. doi: 10.1128/aac.25.1.149. Antimicrob Agents Chemother. 1984. PMID: 6367634 Free PMC article.
In vitro activities of novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems with potent activities against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.
Nagano R, Shibata K, Adachi Y, Imamura H, Hashizume T, Morishima H. Nagano R, et al. Antimicrob Agents Chemother. 2000 Mar;44(3):489-95. doi: 10.1128/aac.44.3.489-495.2000. Antimicrob Agents Chemother. 2000. PMID: 10681308 Free PMC article.
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