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Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization.
Park JH, Na HJ, Kwon YG, Ha KS, Lee SJ, Kim CK, Lee KS, Yoneyama T, Hatakeyama K, Kim PK, Billiar TR, Kim YM. Park JH, et al. Among authors: hatakeyama k. J Biol Chem. 2002 Dec 6;277(49):47073-9. doi: 10.1074/jbc.M207053200. Epub 2002 Sep 30. J Biol Chem. 2002. PMID: 12359727 Free article.
IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells.
Hatakeyama K, Harada T, Kagamiyama H. Hatakeyama K, et al. J Biol Chem. 1992 Oct 15;267(29):20734-9. J Biol Chem. 1992. PMID: 1356983 Free article.
GTP cyclohydrolase I exhibits a positive homotropic cooperative binding to GTP, which raises the possibility of a role for GTP in regulating the enzyme reaction (Hatakeyama, K., Harada, T., Suzuki, S., Watanabe, Y., and Kagamiyama, H. (1989) J. ...
GTP cyclohydrolase I exhibits a positive homotropic cooperative binding to GTP, which raises the possibility of a role for GTP in regulating …
1,570 results