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Oncogenic mechanisms of the Helicobacter pylori CagA protein.
Hatakeyama M. Hatakeyama M. Nat Rev Cancer. 2004 Sep;4(9):688-94. doi: 10.1038/nrc1433. Nat Rev Cancer. 2004. PMID: 15343275 Review.
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.
Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M, Hatakeyama M. Higashi H, et al. Among authors: hatakeyama m. Science. 2002 Jan 25;295(5555):683-6. doi: 10.1126/science.1067147. Epub 2001 Dec 13. Science. 2002. PMID: 11743164
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.
Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, Hatakeyama M. Higashi H, et al. Among authors: hatakeyama m. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14428-33. doi: 10.1073/pnas.222375399. Epub 2002 Oct 21. Proc Natl Acad Sci U S A. 2002. PMID: 12391297 Free PMC article.
Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase.
Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M. Tsutsumi R, et al. Among authors: hatakeyama m. J Biol Chem. 2003 Feb 7;278(6):3664-70. doi: 10.1074/jbc.M208155200. Epub 2002 Nov 21. J Biol Chem. 2003. PMID: 12446738
Deregulation of SHP-2 tyrosine phosphatase by the Helicobacter pylori virulence factor CagA.
Hatakeyama M. Hatakeyama M. Keio J Med. 2002 Dec;51 Suppl 2:26-32. doi: 10.2302/kjm.51.supplement2_26. Keio J Med. 2002. PMID: 12528933
The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa.
Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Higashi H, Hatakeyama M, Azuma T. Yamazaki S, et al. Among authors: hatakeyama m. J Infect Dis. 2003 Jan 15;187(2):334-7. doi: 10.1086/367807. Epub 2002 Dec 19. J Infect Dis. 2003. PMID: 12552462
NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants.
Takebayashi T, Higashi H, Sudo H, Ozawa H, Suzuki E, Shirado O, Katoh H, Hatakeyama M. Takebayashi T, et al. Among authors: hatakeyama m. J Biol Chem. 2003 Apr 25;278(17):14897-905. doi: 10.1074/jbc.M210849200. Epub 2003 Feb 19. J Biol Chem. 2003. PMID: 12594215
Helicobacter pylori CagA--a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins.
Hatakeyama M. Hatakeyama M. Microbes Infect. 2003 Feb;5(2):143-50. doi: 10.1016/s1286-4579(02)00085-0. Microbes Infect. 2003. PMID: 12650772 Review.
The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells.
Azuma T, Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Dojo M, Yamazaki Y, Higashi H, Hatakeyama M. Azuma T, et al. Among authors: hatakeyama m. Aliment Pharmacol Ther. 2003 Jul;18 Suppl 1:39-44. doi: 10.1046/j.1365-2036.18.s1.2.x. Aliment Pharmacol Ther. 2003. PMID: 12925139
Helicobacter pylori CagA as a potential bacterial oncoprotein in gastric carcinogenesis.
Hatakeyama M. Hatakeyama M. Pathol Biol (Paris). 2003 Sep;51(7):393-4. doi: 10.1016/s0369-8114(03)00026-9. Pathol Biol (Paris). 2003. PMID: 12948757 No abstract available.
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