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Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling.
Ishida J, Yamamoto H, Kido Y, Kamijo K, Murano K, Miyake H, Ohkubo M, Kinoshita T, Warizaya M, Iwashita A, Mihara K, Matsuoka N, Hattori K. Ishida J, et al. Among authors: hattori k. Bioorg Med Chem. 2006 Mar 1;14(5):1378-90. doi: 10.1016/j.bmc.2005.09.061. Epub 2005 Nov 8. Bioorg Med Chem. 2006. PMID: 16288880
Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
Iwashita A, Yamazaki S, Mihara K, Hattori K, Yamamoto H, Ishida J, Matsuoka N, Mutoh S. Iwashita A, et al. Among authors: hattori k. J Pharmacol Exp Ther. 2004 Jun;309(3):1067-78. doi: 10.1124/jpet.103.064642. Epub 2004 Feb 25. J Pharmacol Exp Ther. 2004. PMID: 14985416
A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.
Iwashita A, Tojo N, Matsuura S, Yamazaki S, Kamijo K, Ishida J, Yamamoto H, Hattori K, Matsuoka N, Mutoh S. Iwashita A, et al. Among authors: hattori k. J Pharmacol Exp Ther. 2004 Aug;310(2):425-36. doi: 10.1124/jpet.104.066944. Epub 2004 Apr 9. J Pharmacol Exp Ther. 2004. PMID: 15075382
1,740 results