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Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity.
Karpinski J, Hauber I, Chemnitz J, Schäfer C, Paszkowski-Rogacz M, Chakraborty D, Beschorner N, Hofmann-Sieber H, Lange UC, Grundhoff A, Hackmann K, Schrock E, Abi-Ghanem J, Pisabarro MT, Surendranath V, Schambach A, Lindner C, van Lunzen J, Hauber J, Buchholz F. Karpinski J, et al. Among authors: hauber i, hauber j. Nat Biotechnol. 2016 Apr;34(4):401-9. doi: 10.1038/nbt.3467. Epub 2016 Feb 22. Nat Biotechnol. 2016. PMID: 26900663
Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice.
Hauber I, Hofmann-Sieber H, Chemnitz J, Dubrau D, Chusainow J, Stucka R, Hartjen P, Schambach A, Ziegler P, Hackmann K, Schröck E, Schumacher U, Lindner C, Grundhoff A, Baum C, Manz MG, Buchholz F, Hauber J. Hauber I, et al. Among authors: hauber j. PLoS Pathog. 2013;9(9):e1003587. doi: 10.1371/journal.ppat.1003587. Epub 2013 Sep 26. PLoS Pathog. 2013. PMID: 24086129 Free PMC article.
Universal Tre (uTre) recombinase specifically targets the majority of HIV-1 isolates.
Karpinski J, Chemnitz J, Hauber I, Abi-Ghanem J, Paszkowski-Rogacz M, Surendranath V, Chakrabort D, Hackmann K, Schröck E, Pisabarro MT, Hauber J, Buchholz F. Karpinski J, et al. Among authors: hauber i, hauber j. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19706. doi: 10.7448/IAS.17.4.19706. eCollection 2014. J Int AIDS Soc. 2014. PMID: 25397454 Free PMC article.
Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase.
Mariyanna L, Priyadarshini P, Hofmann-Sieber H, Krepstakies M, Walz N, Grundhoff A, Buchholz F, Hildt E, Hauber J. Mariyanna L, et al. Among authors: hauber j. PLoS One. 2012;7(2):e31576. doi: 10.1371/journal.pone.0031576. Epub 2012 Feb 13. PLoS One. 2012. PMID: 22348110 Free PMC article.
167 results