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Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.
Pace BS, Perrine S, Li B, Makala L, Xu H, Takezaki M, Wolf RF, Wang A, Xu X, Huang J, Alimardanov A, Tawa GJ, Sangerman J, Faller A, Zheng W, Toney L, Haugabook SJ. Pace BS, et al. Among authors: haugabook sj. Blood Cells Mol Dis. 2021 Jul;89:102561. doi: 10.1016/j.bcmd.2021.102561. Epub 2021 Mar 12. Blood Cells Mol Dis. 2021. PMID: 33744514 Free PMC article.
In vitro and in vivo translational models for rare liver diseases.
Haugabook SJ, Ferrer M, Ottinger EA. Haugabook SJ, et al. Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):1003-1018. doi: 10.1016/j.bbadis.2018.07.029. Epub 2018 Aug 1. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30075192 Free article. Review.
Discovery of pyrrolidine-based β-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.
Stachel SJ, Steele TG, Petrocchi A, Haugabook SJ, McGaughey G, Katharine Holloway M, Allison T, Munshi S, Zuck P, Colussi D, Tugasheva K, Wolfe A, Graham SL, Vacca JP. Stachel SJ, et al. Among authors: haugabook sj. Bioorg Med Chem Lett. 2012 Jan 1;22(1):240-4. doi: 10.1016/j.bmcl.2011.11.024. Epub 2011 Nov 12. Bioorg Med Chem Lett. 2012. PMID: 22130130
A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason.
Hills ID, Holloway MK, de León P, Nomland A, Zhu H, Rajapakse H, Allison TJ, Munshi SK, Colussi D, Pietrak BL, Toolan D, Haugabook SJ, Graham SL, Stachel SJ. Hills ID, et al. Among authors: haugabook sj. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4993-5. doi: 10.1016/j.bmcl.2009.07.071. Epub 2009 Jul 17. Bioorg Med Chem Lett. 2009. PMID: 19640712
11 results