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Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus-neutralizing activity in vaccinated mice.
Dobrica MO, van Eerde A, Tucureanu C, Onu A, Paruch L, Caras I, Vlase E, Steen H, Haugslien S, Alonzi D, Zitzmann N, Bock R, Dubuisson J, Popescu CI, Stavaru C, Liu Clarke J, Branza-Nichita N. Dobrica MO, et al. Among authors: haugslien s. Plant Biotechnol J. 2021 Oct;19(10):2027-2039. doi: 10.1111/pbi.13631. Epub 2021 Jun 3. Plant Biotechnol J. 2021. PMID: 34002936 Free PMC article.
Lettuce-produced hepatitis C virus E1E2 heterodimer triggers immune responses in mice and antibody production after oral vaccination.
Clarke JL, Paruch L, Dobrica MO, Caras I, Tucureanu C, Onu A, Ciulean S, Stavaru C, Eerde A, Wang Y, Steen H, Haugslien S, Petrareanu C, Lazar C, Popescu CI, Bock R, Dubuisson J, Branza-Nichita N. Clarke JL, et al. Among authors: haugslien s. Plant Biotechnol J. 2017 Dec;15(12):1611-1621. doi: 10.1111/pbi.12743. Epub 2017 Jun 9. Plant Biotechnol J. 2017. PMID: 28419665 Free PMC article.
A novel chimeric Hepatitis B virus S/preS1 antigen produced in mammalian and plant cells elicits stronger humoral and cellular immune response than the standard vaccine-constituent, S protein.
Dobrica MO, Lazar C, Paruch L, Skomedal H, Steen H, Haugslien S, Tucureanu C, Caras I, Onu A, Ciulean S, Branzan A, Clarke JL, Stavaru C, Branza-Nichita N. Dobrica MO, et al. Among authors: haugslien s. Antiviral Res. 2017 Aug;144:256-265. doi: 10.1016/j.antiviral.2017.06.017. Epub 2017 Jun 27. Antiviral Res. 2017. PMID: 28666757
The "humanized" N-glycosylation pathway in CRISPR/Cas9-edited Nicotiana benthamiana significantly enhances the immunogenicity of a S/preS1 Hepatitis B Virus antigen and the virus-neutralizing antibody response in vaccinated mice.
Pantazica AM, van Eerde A, Dobrica MO, Caras I, Ionescu I, Costache A, Tucureanu C, Steen H, Lazar C, Heldal I, Haugslien S, Onu A, Stavaru C, Branza-Nichita N, Liu Clarke J. Pantazica AM, et al. Among authors: haugslien s. Plant Biotechnol J. 2023 Jun;21(6):1176-1190. doi: 10.1111/pbi.14028. Epub 2023 Mar 10. Plant Biotechnol J. 2023. PMID: 36779605 Free PMC article.