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Trends in GPCR drug discovery: new agents, targets and indications.
Hauser AS, Attwood MM, Rask-Andersen M, Schiöth HB, Gloriam DE. Hauser AS, et al. Nat Rev Drug Discov. 2017 Dec;16(12):829-842. doi: 10.1038/nrd.2017.178. Epub 2017 Oct 27. Nat Rev Drug Discov. 2017. PMID: 29075003 Free PMC article. Review.
GPCRdb: an information system for G protein-coupled receptors.
Isberg V, Mordalski S, Munk C, Rataj K, Harpsøe K, Hauser AS, Vroling B, Bojarski AJ, Vriend G, Gloriam DE. Isberg V, et al. Among authors: hauser as. Nucleic Acids Res. 2016 Jan 4;44(D1):D356-64. doi: 10.1093/nar/gkv1178. Epub 2015 Nov 17. Nucleic Acids Res. 2016. PMID: 26582914 Free PMC article.
GPCRdb: the G protein-coupled receptor database - an introduction.
Munk C, Isberg V, Mordalski S, Harpsøe K, Rataj K, Hauser AS, Kolb P, Bojarski AJ, Vriend G, Gloriam DE. Munk C, et al. Among authors: hauser as. Br J Pharmacol. 2016 Jul;173(14):2195-207. doi: 10.1111/bph.13509. Epub 2016 Jun 3. Br J Pharmacol. 2016. PMID: 27155948 Free PMC article. Review.
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Nøhr AC, Shehata MA, Hauser AS, Isberg V, Mokrosinski J, Andersen KB, Farooqi IS, Pedersen DS, Gloriam DE, Bräuner-Osborne H. Nøhr AC, et al. Among authors: hauser as. Neurochem Int. 2017 Jan;102:105-113. doi: 10.1016/j.neuint.2016.11.012. Epub 2016 Dec 1. Neurochem Int. 2017. PMID: 27916541 Free PMC article.
Selectivity determinants of GPCR-G-protein binding.
Flock T, Hauser AS, Lund N, Gloriam DE, Balaji S, Babu MM. Flock T, et al. Among authors: hauser as. Nature. 2017 May 18;545(7654):317-322. doi: 10.1038/nature22070. Epub 2017 May 10. Nature. 2017. PMID: 28489817 Free PMC article.
GPCRdb in 2018: adding GPCR structure models and ligands.
Pándy-Szekeres G, Munk C, Tsonkov TM, Mordalski S, Harpsøe K, Hauser AS, Bojarski AJ, Gloriam DE. Pándy-Szekeres G, et al. Among authors: hauser as. Nucleic Acids Res. 2018 Jan 4;46(D1):D440-D446. doi: 10.1093/nar/gkx1109. Nucleic Acids Res. 2018. PMID: 29155946 Free PMC article.
Pharmacogenomics of GPCR Drug Targets.
Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM. Hauser AS, et al. Cell. 2018 Jan 11;172(1-2):41-54.e19. doi: 10.1016/j.cell.2017.11.033. Epub 2017 Dec 14. Cell. 2018. PMID: 29249361 Free PMC article.
30 results