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344 results
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Use of mitochondrial antioxidant defenses for rescue of cells with a Leber hereditary optic neuropathy-causing mutation.
Qi X, Sun L, Hauswirth WW, Lewin AS, Guy J. Qi X, et al. Among authors: hauswirth ww. Arch Ophthalmol. 2007 Feb;125(2):268-72. doi: 10.1001/archopht.125.2.268. Arch Ophthalmol. 2007. PMID: 17296905
Development of hammerhead ribozymes to modulate endogenous gene expression for functional studies.
Fritz JJ, Lewin A, Hauswirth W, Agarwal A, Grant M, Shaw L. Fritz JJ, et al. Methods. 2002 Oct;28(2):276-85. doi: 10.1016/s1046-2023(02)00233-5. Methods. 2002. PMID: 12413427
Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
Loiler SA, Tang Q, Clarke T, Campbell-Thompson ML, Chiodo V, Hauswirth W, Cruz P, Perret-Gentil M, Atkinson MA, Ramiya VK, Flotte TR. Loiler SA, et al. Mol Ther. 2005 Sep;12(3):519-27. doi: 10.1016/j.ymthe.2005.04.017. Mol Ther. 2005. PMID: 15979413
Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial.
Ghazi NG, Abboud EB, Nowilaty SR, Alkuraya H, Alhommadi A, Cai H, Hou R, Deng WT, Boye SL, Almaghamsi A, Al Saikhan F, Al-Dhibi H, Birch D, Chung C, Colak D, LaVail MM, Vollrath D, Erger K, Wang W, Conlon T, Zhang K, Hauswirth W, Alkuraya FS. Ghazi NG, et al. Hum Genet. 2016 Mar;135(3):327-43. doi: 10.1007/s00439-016-1637-y. Epub 2016 Jan 29. Hum Genet. 2016. PMID: 26825853 Clinical Trial.
Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III.
Geng R, Omar A, Gopal SR, Chen DH, Stepanyan R, Basch ML, Dinculescu A, Furness DN, Saperstein D, Hauswirth W, Lustig LR, Alagramam KN. Geng R, et al. Sci Rep. 2017 Oct 18;7(1):13480. doi: 10.1038/s41598-017-13620-9. Sci Rep. 2017. PMID: 29044151 Free PMC article.
Longterm Reversal of Severe Visual Loss by Mitochondrial Gene Transfer in a Mouse Model of Leber Hereditary Optic Neuropathy.
Yu H, Porciatti V, Lewin A, Hauswirth W, Guy J. Yu H, et al. Sci Rep. 2018 Apr 3;8(1):5587. doi: 10.1038/s41598-018-23836-y. Sci Rep. 2018. PMID: 29615737 Free PMC article.
Reprogramming adipose tissue-derived mesenchymal stem cells into pluripotent stem cells by a mutant adeno-associated viral vector.
Chen MJ, Lu Y, Hamazaki T, Tsai HY, Erger K, Conlon T, Elshikha AS, Li H, Srivastava A, Yao C, Brantly M, Chiodo V, Hauswirth W, Terada N, Song S. Chen MJ, et al. Hum Gene Ther Methods. 2014 Feb;25(1):72-82. doi: 10.1089/hgtb.2013.011. Epub 2013 Dec 28. Hum Gene Ther Methods. 2014. PMID: 24191859 Free PMC article.
Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve.
Guy J, Qi X, Muzyczka N, Hauswirth WW. Guy J, et al. Among authors: hauswirth ww. Arch Ophthalmol. 1999 Jul;117(7):929-37. doi: 10.1001/archopht.117.7.929. Arch Ophthalmol. 1999. PMID: 10408459
Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis.
Guy J, Qi X, Hauswirth WW. Guy J, et al. Among authors: hauswirth ww. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13847-52. doi: 10.1073/pnas.95.23.13847. Proc Natl Acad Sci U S A. 1998. PMID: 9811889 Free PMC article.
AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury.
Kwong JM, Gu L, Nassiri N, Bekerman V, Kumar-Singh R, Rhee KD, Yang XJ, Hauswirth WW, Caprioli J, Piri N. Kwong JM, et al. Among authors: hauswirth ww. Gene Ther. 2015 Feb;22(2):138-45. doi: 10.1038/gt.2014.105. Epub 2014 Nov 27. Gene Ther. 2015. PMID: 25427613 Free PMC article.
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