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Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase.
Zatloukal M, Gemrotová M, Dolezal K, Havlícek L, Spíchal L, Strnad M. Zatloukal M, et al. Among authors: havlicek l. Bioorg Med Chem. 2008 Oct 15;16(20):9268-75. doi: 10.1016/j.bmc.2008.09.008. Epub 2008 Sep 7. Bioorg Med Chem. 2008. PMID: 18818088
Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines.
Jorda R, Sacerdoti-Sierra N, Voller J, Havlíček L, Kráčalíková K, Nowicki MW, Nasereddin A, Kryštof V, Strnad M, Walkinshaw MD, Jaffe CL. Jorda R, et al. Among authors: havlicek l. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4233-7. doi: 10.1016/j.bmcl.2011.05.076. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21683592
Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin.
Krystof V, Moravcová D, Paprskárová M, Barbier P, Peyrot V, Hlobilková A, Havlícek L, Strnad M. Krystof V, et al. Among authors: havlicek l. Eur J Med Chem. 2006 Dec;41(12):1405-11. doi: 10.1016/j.ejmech.2006.07.004. Epub 2006 Sep 22. Eur J Med Chem. 2006. PMID: 16996651
2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro.
Řezníčková E, Popa A, Gucký T, Zatloukal M, Havlíček L, Bazgier V, Berka K, Jorda R, Popa I, Nasereddin A, Jaffe CL, Kryštof V, Strnad M. Řezníčková E, et al. Among authors: havlicek l. Bioorg Med Chem Lett. 2015 Jun 1;25(11):2298-301. doi: 10.1016/j.bmcl.2015.04.030. Epub 2015 Apr 16. Bioorg Med Chem Lett. 2015. PMID: 25937014
Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity.
Jorda R, Havlícek L, McNae IW, Walkinshaw MD, Voller J, Sturc A, Navrátilová J, Kuzma M, Mistrík M, Bártek J, Strnad M, Krystof V. Jorda R, et al. Among authors: havlicek l. J Med Chem. 2011 Apr 28;54(8):2980-93. doi: 10.1021/jm200064p. Epub 2011 Apr 6. J Med Chem. 2011. PMID: 21417417
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.
Vymětalová L, Havlíček L, Šturc A, Skrášková Z, Jorda R, Pospíšil T, Strnad M, Kryštof V. Vymětalová L, et al. Among authors: havlicek l. Eur J Med Chem. 2016 Mar 3;110:291-301. doi: 10.1016/j.ejmech.2016.01.011. Epub 2016 Jan 18. Eur J Med Chem. 2016. PMID: 26851505
Characterization of a Pyrazolo[4,3-d]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro.
Řezníčková E, Weitensteiner S, Havlíček L, Jorda R, Gucký T, Berka K, Bazgier V, Zahler S, Kryštof V, Strnad M. Řezníčková E, et al. Among authors: havlicek l. Chem Biol Drug Des. 2015 Dec;86(6):1528-40. doi: 10.1111/cbdd.12618. Epub 2015 Sep 16. Chem Biol Drug Des. 2015. PMID: 26198005
8-Azapurines as new inhibitors of cyclin-dependent kinases.
Havlicek L, Fuksova K, Krystof V, Orsag M, Vojtesek B, Strnad M. Havlicek L, et al. Bioorg Med Chem. 2005 Sep 15;13(18):5399-407. doi: 10.1016/j.bmc.2005.06.007. Bioorg Med Chem. 2005. PMID: 15993080
2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.
Moravec J, Krystof V, Hanus J, Havlícek L, Moravcová D, Fuksová K, Kuzma M, Lenobel R, Otyepka M, Strnad M. Moravec J, et al. Among authors: havlicek l. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2993-6. doi: 10.1016/s0960-894x(03)00632-2. Bioorg Med Chem Lett. 2003. PMID: 12941319
Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.
Moravcová D, Krystof V, Havlícek L, Moravec J, Lenobel R, Strnad M. Moravcová D, et al. Among authors: havlicek l. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2989-92. doi: 10.1016/s0960-894x(03)00631-0. Bioorg Med Chem Lett. 2003. PMID: 12941318
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