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Developing novel oncolytic adenoviruses through bioselection.
Yan W, Kitzes G, Dormishian F, Hawkins L, Sampson-Johannes A, Watanabe J, Holt J, Lee V, Dubensky T, Fattaey A, Hermiston T, Balmain A, Shen Y. Yan W, et al. Among authors: hawkins l. J Virol. 2003 Feb;77(4):2640-50. doi: 10.1128/jvi.77.4.2640-2650.2003. J Virol. 2003. PMID: 12552003 Free PMC article.
Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer.
Ryan PC, Jakubczak JL, Stewart DA, Hawkins LK, Cheng C, Clarke LM, Ganesh S, Hay C, Huang Y, Kaloss M, Marinov A, Phipps SS, Reddy PS, Shirley PS, Skripchenko Y, Xu L, Yang J, Forry-Schaudies S, Hallenbeck PL. Ryan PC, et al. Among authors: hawkins lk. Cancer Gene Ther. 2004 Aug;11(8):555-69. doi: 10.1038/sj.cgt.7700735. Cancer Gene Ther. 2004. PMID: 15232601
An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy.
Jakubczak JL, Ryan P, Gorziglia M, Clarke L, Hawkins LK, Hay C, Huang Y, Kaloss M, Marinov A, Phipps S, Pinkstaff A, Shirley P, Skripchenko Y, Stewart D, Forry-Schaudies S, Hallenbeck PL. Jakubczak JL, et al. Among authors: hawkins lk. Cancer Res. 2003 Apr 1;63(7):1490-9. Cancer Res. 2003. PMID: 12670895
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