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The blood-brain barrier and glutamate.
Hawkins RA. Hawkins RA. Am J Clin Nutr. 2009 Sep;90(3):867S-874S. doi: 10.3945/ajcn.2009.27462BB. Epub 2009 Jul 1. Am J Clin Nutr. 2009. PMID: 19571220 Free PMC article.
GLUT-1 glucose transporters in the blood-brain barrier: differential phosphorylation.
Devraj K, Klinger ME, Myers RL, Mokashi A, Hawkins RA, Simpson IA. Devraj K, et al. Among authors: hawkins ra. J Neurosci Res. 2011 Dec;89(12):1913-25. doi: 10.1002/jnr.22738. Epub 2011 Sep 9. J Neurosci Res. 2011. PMID: 21910135 Free PMC article.
Structure of the blood-brain barrier and its role in the transport of amino acids.
Hawkins RA, O'Kane RL, Simpson IA, Viña JR. Hawkins RA, et al. J Nutr. 2006 Jan;136(1 Suppl):218S-26S. doi: 10.1093/jn/136.1.218S. J Nutr. 2006. PMID: 16365086 Review.
Cationic amino acid transport across the blood-brain barrier is mediated exclusively by system y+.
O'Kane RL, Viña JR, Simpson I, Zaragozá R, Mokashi A, Hawkins RA. O'Kane RL, et al. Among authors: hawkins ra. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E412-9. doi: 10.1152/ajpendo.00007.2006. Epub 2006 Mar 28. Am J Physiol Endocrinol Metab. 2006. PMID: 16569760
How Glutamate Is Managed by the Blood-Brain Barrier.
Hawkins RA, Viña JR. Hawkins RA, et al. Biology (Basel). 2016 Oct 8;5(4):37. doi: 10.3390/biology5040037. Biology (Basel). 2016. PMID: 27740595 Free PMC article. Review.
BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.
Devraj K, Poznanovic S, Spahn C, Schwall G, Harter PN, Mittelbronn M, Antoniello K, Paganetti P, Muhs A, Heilemann M, Hawkins RA, Schrattenholz A, Liebner S. Devraj K, et al. Among authors: hawkins ra. J Cereb Blood Flow Metab. 2016 Jul;36(7):1281-94. doi: 10.1177/0271678X15606463. Epub 2015 Oct 13. J Cereb Blood Flow Metab. 2016. PMID: 26661166 Free PMC article.
Na(+)-dependent transport of taurine is found only on the abluminal membrane of the blood-brain barrier.
Rasgado-Flores H, Mokashi A, Hawkins RA. Rasgado-Flores H, et al. Among authors: hawkins ra. Exp Neurol. 2012 Jan;233(1):457-62. doi: 10.1016/j.expneurol.2011.11.019. Epub 2011 Nov 19. Exp Neurol. 2012. PMID: 22123083
Glutamate permeability at the blood-brain barrier in insulinopenic and insulin-resistant rats.
Hawkins RA, Mokashi A, Dejoseph MR, Viña JR, Fernstrom JD. Hawkins RA, et al. Metabolism. 2010 Feb;59(2):258-66. doi: 10.1016/j.metabol.2009.07.022. Epub 2009 Sep 29. Metabolism. 2010. PMID: 19793593 Free PMC article.
Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier.
Hawkins RA, Simpson IA, Mokashi A, Viña JR. Hawkins RA, et al. FEBS Lett. 2006 Aug 7;580(18):4382-6. doi: 10.1016/j.febslet.2006.06.097. Epub 2006 Jul 10. FEBS Lett. 2006. PMID: 16844120
An active transport system in the blood-brain barrier may reduce levodopa availability.
Hawkins RA, Mokashi A, Simpson IA. Hawkins RA, et al. Exp Neurol. 2005 Sep;195(1):267-71. doi: 10.1016/j.expneurol.2005.04.008. Exp Neurol. 2005. PMID: 15925365
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