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The Akt-mTOR tango and its relevance to cancer.
Hay N. Hay N. Cancer Cell. 2005 Sep;8(3):179-83. doi: 10.1016/j.ccr.2005.08.008. Cancer Cell. 2005. PMID: 16169463 Review.
The effect Akt2 deletion on tumor development in Pten(+/-) mice.
Xu PZ, Chen ML, Jeon SM, Peng XD, Hay N. Xu PZ, et al. Among authors: hay n. Oncogene. 2012 Jan 26;31(4):518-26. doi: 10.1038/onc.2011.243. Epub 2011 Jul 11. Oncogene. 2012. PMID: 21743498 Free PMC article.
Expanding the concepts of cancer metabolism.
Jeon SM, Hay N. Jeon SM, et al. Among authors: hay n. Exp Mol Med. 2018 Apr 16;50(4):32. doi: 10.1038/s12276-018-0070-9. Exp Mol Med. 2018. PMID: 29657329 Free PMC article. No abstract available.
Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation.
Nogueira V, Patra KC, Hay N. Nogueira V, et al. Among authors: hay n. Elife. 2018 Apr 24;7:e32213. doi: 10.7554/eLife.32213. Elife. 2018. PMID: 29687779 Free PMC article.
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.
Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N. Patra KC, et al. Among authors: hay n. Cancer Cell. 2013 Aug 12;24(2):213-228. doi: 10.1016/j.ccr.2013.06.014. Epub 2013 Aug 1. Cancer Cell. 2013. PMID: 23911236 Free PMC article.
AMPK as a therapeutic target in renal cell carcinoma.
Woodard J, Joshi S, Viollet B, Hay N, Platanias LC. Woodard J, et al. Among authors: hay n. Cancer Biol Ther. 2010 Dec 1;10(11):1168-77. doi: 10.4161/cbt.10.11.13629. Epub 2010 Dec 1. Cancer Biol Ther. 2010. PMID: 20948309 Free PMC article.
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.
Jeon SM, Chandel NS, Hay N. Jeon SM, et al. Among authors: hay n. Nature. 2012 May 9;485(7400):661-5. doi: 10.1038/nature11066. Nature. 2012. PMID: 22660331 Free PMC article.
Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.
Sudhahar V, Okur MN, Bagi Z, O'Bryan JP, Hay N, Makino A, Patel VS, Phillips SA, Stepp D, Ushio-Fukai M, Fukai T. Sudhahar V, et al. Among authors: hay n. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):529-541. doi: 10.1161/ATVBAHA.117.309819. Epub 2018 Jan 4. Arterioscler Thromb Vasc Biol. 2018. PMID: 29301787 Free PMC article.
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.
Kerr BA, West XZ, Kim YW, Zhao Y, Tischenko M, Cull RM, Phares TW, Peng XD, Bernier-Latmani J, Petrova TV, Adams RH, Hay N, Naga Prasad SV, Byzova TV. Kerr BA, et al. Among authors: hay n. Nat Commun. 2016 Mar 14;7:10960. doi: 10.1038/ncomms10960. Nat Commun. 2016. PMID: 26971877 Free PMC article.
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.
Ding L, Biswas S, Morton RE, Smith JD, Hay N, Byzova TV, Febbraio M, Podrez EA. Ding L, et al. Among authors: hay n. Cell Metab. 2012 Jun 6;15(6):861-72. doi: 10.1016/j.cmet.2012.04.020. Epub 2012 May 24. Cell Metab. 2012. PMID: 22632897 Free PMC article.
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